Results 141 to 150 of about 614,734 (318)

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver

, 2005
The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period.
J A Ross, Wheelhouse, Nicholas M, D J Harrison, Wigmore, S J, Lai, P B S, P B S Lai, Wheelhouse, N M, Ross, J A, Harrison, D J, N M Wheelhouse, S J Wigmore   +10 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria

, 1967
The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
core   +1 more source

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Recombinant Mitochondrial Transcription Factor A with N-terminal Mitochondrial Transduction Domain Increases Respiration and Mitochondrial Gene Expression in G11778A Leber's Hereditary Optic Neuropathy Cybrid Cells

, 2008
Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics.
James P. Bennett, Ravindar R. Thomas, Shilpa Iyer, Francisco R. Portell, Caitlin K. Quigley, Lisa D. Dunahm   +5 more
core  

Wolbachia and DNA barcoding insects: patterns, potential and problems

, 2012
Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are ...
Janzen, D H, Mark R. Shaw (167095), Packer , L, Julie K. Stahlhut (167104), Claudia Bertrand (167052), Dirk Steinke, Xin Zhou, Crosby, K, Yanwei Li (167076), Quicke Donald, Quicke, D, Eveleigh Eldon S., Monty Wood, Steinke Dirk, Stahlhut, J K, Katharine Hind, Fernandez-Triana, J, Shaw, Mark R, Winnie Hallwachs, Hind Katharine, Ratnasingham, S, Da-Wei Huang, Yanwei, L, Katharine Hind (167065), Julie K Stahlhut, Bertrand, C, Eldon S. Eveleigh (167054), Hind, K, Daniel H Janzen, Jason Gibbs (167056), Brian L Fisher, Fisher, B L, Cory Sheffield, Mehrdad Hajibabaei, James Whitfield (167108), Monty Wood (167110), Miller Scott E., Josephine Rodriguez, Brian L. Fisher (47870), Sujeevan Ratnasingham (167085), Kate Crosby, Donald Quicke, Wood Monty, Janda Milan, Jan Hrcek (167068), Huang Da-Wei, Ratnasingham Sujeevan, Gibbs, J, Hallwachs Winnie, Huang, D W, Rodriguez, J J, Kate Crosby (167053), Laurence Packer, Scott E. Miller (167079), Eldon S Eveleigh, Smith M. Alex, James Whitfield, Zhou, X, Scott E Miller, Zhou Xin, Rodolphe Rougerie (134289), Yanwei Li, Janda, M, Crosby Kate, Hrcek, J, Cory Sheffield (167100), Whitfield, J B, Jason Gibbs, Wood, M, M Alex Smith, Rodolphe Rougerie, Smith, M A, Sheffield Cory, Rougerie Rodolphe, Hallwachs, W, Donald Quicke (167083), Fisher Brian L., Sheffield, C, Jan Hrcek, Rodriguez Josephine, Mehrdad Hajibabaei (76205), Packer Laurence, Stahlhut Julie K., Whitfield James, M. Alex Smith (47871), Winnie Hallwachs (167061), Wood , M, Milan Janda, Bertrand Claudia, Gibbs Jason, Da-Wei Huang (102802), Miller, S E, Dirk Steinke (15543), Laurence Packer (167080), Mark R Shaw, Li Yanwei, Packer, L, Hajibabaei Mehrdad, Rougerie, R, Claudia Bertrand, Hrcek Jan, Sujeevan Ratnasingham, Daniel H. Janzen (167074), Fernandez-Triana Jose, Steinke, D, Jose Fernandez-Triana (167055), Milan Janda (167072), Josephine Rodriguez (167090), Hajibabaei, M, Xin Zhou (54275), Jose Fernandez-Triana, Janzen Daniel H., Shaw Mark R., Eveleigh, E S, Janda , M   +114 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Mitochondrial DNA signals of late glacial recolonization of Europe from near Eastern refugia

, 2012
Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age.
Reisberg T., Tamm, Erika, Karmin, M., Pereira, L., Al Zahery N., Houshmand M., Tamm, E, Macaulay V, Reisberg, T., Pala M., Gamble C., Villems R, Houshmand M, Macaulay, V., Karmin M., Hatina J, Reisberg, Tuuli, Gamble, Clive, Kashani, Baharak Hooshiar, Accetturo, M., Baird D, Woodward S. R., Woodward SR, Accetturo, M, Reidla, M, Sanati, Mohammad Hossein, Gamble, C, Davies W, Carossa, V., Karmin M, Achilli, A., Kashani, B.H., Reisberg, T, Carelli, Valerio, Macaulay, Vincent, Tamm E, Soares, Pedro, Achilli, A, Torroni, Antonio, Sanati M. H., Soares, P, Woodward, SR, Hooshiar Kashani, Baharak, Carossa, V, Torroni, A, Villems, Richard, Rychkov, Sergei, Rychkov S, Richards, MB, Metspalu E., Gandini, F., Karmin, Monika, Pereira, Joana B., Al Zahery N, Metspalu, E., Richards, M.B., PEREGO, UGO ALESSANDRO, Achilli A., Semino, O, Soares P., Olivieri, A, Soares P, Karmin, M, Angerhofer N, Carelli, V., Torroni A., Hatina J., Pala, M., Pereira L, Davies, W, Villems, R, Carelli V, Pereira, J.B., Perego, U.A., Davies, William, Richards MB, Gandini, F, Torroni, A., Reidla, Maere, Olivieri A., Olivieri, Anna, Hatina, J, Perego, Ugo A., Semino, O., Davies, W., Woodward, Scott R., Baird D., Richards M. B., Hooshiar Kashani B., Macaulay V., Villems R., Al-Zahery, N, Metspalu, E, Rychkov, S., Pereira L., Al-Zahery, N., Baird, Douglas, Reisberg T, Angerhofer, N, Pereira JB, Pereira, L, Gandini, Francesca, Gamble C, Sanati MH, Olivieri, A., Hatina, J., Accetturo, Matteo, Pereira, Luísa, Gamble, C., Houshmand, Massoud, Pala, M, Carossa, Valeria, Woodward, S.R., Reidla M, Hossein Sanati, M, Pala, Maria, Angerhofer N., Semino O., Al-Zahery, Nadia, Metspalu, Ene, Davies W., Macaulay, V, Perego U. A., Houshmand, M., Angerhofer, N., Sanati, M.H., Houshmand, M, Tamm E., Pereira, JB, Baird, D, Metspalu E, Achilli, Alessandro, Angerhofer, Norman, Carelli, V, Semino, Ornella, Villems, R., Pereira J. B., Carossa V., Reidla M., Rychkov S., Hooshiar Kashani, B, Perego, UA, Hatina, Jiři, Richards, Martin B., Baird, D., Soares, P., Gandini F., Accetturo M., Rychkov, S   +148 more
core   +1 more source

Circulating cell-free mitochondrial DNA for diagnosing hepatocellular carcinoma and assessing prognosis: Editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Hyuk soo Eun
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source