Results 241 to 250 of about 904,843 (281)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Targeting the epigenome and tumor heterogeneity: advances in immunotherapy for chemoresistant metastatic colorectal cancer. [PDF]

Front Immunol
Cao Y, Beeraka NM, Efetov SK, Liu Z, Otabekov AA, Basappa B, Wang W, Ma D.   +7 more
europepmc   +1 more source

Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction. [PDF]

Sci Rep
Mohamed HRH, Magdy H, Elberry Y, Ismail M, Michael M, Eltayeb N, Safwat G, Diab A.   +7 more
europepmc   +1 more source

Exploring Mitochondrial DNA Copy Number in Italian Children with ADHD: Implications for Neurobiological Mechanisms. [PDF]

Diseases
Citrigno L, Cerantonio A, Neri L, Sebastiani P, Colanardi A, Turacchio G, Del Beato T, Marziani B, Aureli A.   +8 more
europepmc   +1 more source

The complete mitochondrial genome and phylogenetic analysis of <i>Hemidactylus bowringii</i> (Squamata: Gekkonidae). [PDF]

Mitochondrial DNA B Resour
Jiao H, Hu P, Zhu Z, Ye X, Wu Z, Chen J, Liu Z, Teng L.   +7 more
europepmc   +1 more source

Spectrum and Impact of Mitochondrial DNA Mutations in Ovarian Cancer. [PDF]

Int J Mol Sci
Low SSP, Greaves L, Silk R, Semple CA, Gourley C.   +4 more
europepmc   +1 more source

Methionine Adenosyltransferase 1A and S-Adenosylmethionine in Alcohol-Associated Liver Disease. [PDF]

Antioxidants (Basel)
Barbier-Torres L, Chhimwal J, Mato JM, Lu SC.   +3 more
europepmc   +1 more source

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Mitochondrial DNA mutators

Cellular and Molecular Life Sciences, 2004
In this article we review our current knowledge of the mechanisms by which point mutations arise in the mitochondrial DNA (mtDNA) of Saccharomyces cerevisiae and discuss to what extent these mechanisms operate in human mtDNA mutagenesis. The 3'-5' exonuclease proofreading activity of Pol gamma ensures accuracy of mtDNA replication in both yeast and ...
F, Foury, J, Hu, S, Vanderstraeten
openaire   +2 more sources

Mitochondrial DNA Analysis

2023
Mitochondrial DNA (mtDNA) is a 16,569 base pair (bp) circular genome that is passed from generation to generation through the maternal line. mtDNA analysis in the context of the forensic science field usually involves unidentified human remains or missing persons. These cases tend to have more challenging sample types (e.g., rootless hairs, bone, blood,
openaire   +2 more sources