Results 241 to 250 of about 3,128,275 (354)

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

FEBS Letters, 2018
Nadee Nissanka, C. Moraes
semanticscholar   +1 more source

Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia-reperfusion injury through inhibition of cell death storm. [PDF]

J Nanobiotechnology
Ye K, Lin K, Wu C, Zou Z, Zhu Y, Xu Y.
europepmc   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

The complete mitochondrial genome of <i>Halichoeres margaritaceus</i> (Actinopterygii, Labridae). [PDF]

Mitochondrial DNA B Resour
Huang X, Zhou Q, Xu Y, Dong Q, Fang S, Li X, Wu Y, Cai X.   +7 more
europepmc   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

The complete mitochondrial genome of the widespread freshwater limpet <i>Ferrissia californica</i>. [PDF]

Mitochondrial DNA B Resour
Kachlishvili N, Schneider C, Bikashvili A, Feldmeyer B, Pfenninger M, Mumladze L.   +5 more
europepmc   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression. [PDF]

Front Microbiol
Zhao H, Qiu X, Wang S, Wang Y, Xie L, Xia X, Li W.   +6 more
europepmc   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

Characterization of the complete mitochondrial genome and phylogenetic analysis of the Southern giant petrel (<i>Macronectes giganteus</i>, Procellariiformes: Procellariidae). [PDF]

Mitochondrial DNA B Resour
Kim JU, Kim JH.
europepmc   +1 more source