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Mitochondrial Oxidative Stress and Mitochondrial DNA
Clinical Chemistry and Laboratory Medicine, 2003Mitochondria produce reactive oxygen species (ROS) under physiological conditions in association with activity of the respiratory chain in aerobic ATP production. The production of ROS is essentially a function of O2 consumption. Hence, increased mitochondrial activity per se can be an oxidative stress to cells.
Dongchon, Kang, Naotaka, Hamasaki
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European Journal of Pediatrics, 2000
Over 100 pathogenic point mutations and 200 deletions, insertions, and rearrangements have been identified since the first mitochondrial DNA mutations were described in 1988. About 60% of the point mutations affect mitochondrial tRNAs, 35% affect polypeptide subunits of the respiratory chain, and 5% affect mitochondrial ribosomal RNAs.
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Over 100 pathogenic point mutations and 200 deletions, insertions, and rearrangements have been identified since the first mitochondrial DNA mutations were described in 1988. About 60% of the point mutations affect mitochondrial tRNAs, 35% affect polypeptide subunits of the respiratory chain, and 5% affect mitochondrial ribosomal RNAs.
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Mitochondrial DNA polymorphism in mitochondrial myopathy
Human Genetics, 1988In order to test the hypothesis that mitochondrial myopathy may be caused by mutation of the mitochondrial (mt) genome, restriction fragment length polymorphism in leucocyte mt DNA has been studied in 38 patients with mitochondrial myopathy, 44 of their unaffected matrilineal relatives, and 35 normal control subjects.
I J, Holt +2 more
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2018
Mitochondrial DNA (mtDNA) is the only DNA found outside the nucleus of the cell. It has a number of useful properties for anthropological studies, including a rapid rate of evolution, maternal mode of inheritance, and being present in hundreds to thousands of copies per cell.
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Mitochondrial DNA (mtDNA) is the only DNA found outside the nucleus of the cell. It has a number of useful properties for anthropological studies, including a rapid rate of evolution, maternal mode of inheritance, and being present in hundreds to thousands of copies per cell.
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
E F, van Bruggen +4 more
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E F, van Bruggen +4 more
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Molecular mechanisms and consequences of mitochondrial permeability transition
Nature Reviews Molecular Cell Biology, 2021Massimo Bonora +2 more
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Mechanisms of mitochondrial respiratory adaptation
Nature Reviews Molecular Cell Biology, 2022Christopher F Bennett +2 more
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