Results 251 to 260 of about 2,421,986 (315)

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

The mitochondrial DNA-cGAS-STING axis in colorectal cancer: a focused review of context-dependent roles and therapeutic opportunities. [PDF]

Front Mol Biosci
Gui H, Zhang Y, Yuan X.
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Dietary Vitamin K2 Isoforms Restore Redox Balance, Organelle Integrity, and Genomic Stability under Streptozotocin-Induced Oxidative Stress in Differentiated SH-SY5Y Cells. [PDF]

J Agric Food Chem
Shandilya S, Ruokolainen J.
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Comparative Toxicological Profiling Reveals Divergent Redox, Mitochondrial, and Cellular Toxicity to Structurally Diverse Opioids. [PDF]

J Xenobiot
Pizent A, Zandona A, Jurič A, Tariba Lovaković B, Rašić D, Kopjar N, Vuković K, Katalinić M, Rešić A, Canjuga I, Vrdoljak AL, Karačonji IB.   +11 more
europepmc   +1 more source

Complete Mitochondrial Genome of a French Bulldog with <i>Carcinoma planoepitheliale keratodes G1</i>: A Descriptive Case Report. [PDF]

Genes (Basel)
Kowal K, Ziółkowska-Twarowska K, Kiecak B, Ozga N, Tkaczyk-Wlizło A, Grychnik P, Grzybowska-Szatkowska L, Ślaska B.   +7 more
europepmc   +1 more source

SIRT1-Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions. [PDF]

Biology (Basel)
Yan M, Hua L, He Y, Li Y, Yang Q, Chen Y.   +5 more
europepmc   +1 more source