Results 191 to 200 of about 3,320,596 (325)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

A review of vaccinology and <i>ex vivo</i> antigen-loaded dendritic cells: A different approach to infectious disease vaccines. [PDF]

Hum Vaccin Immunother
Dillman RO, Nistor GI, Keirstead HS.
europepmc   +1 more source

Interference of humic acids and DNA extracted directly from soil in detection and transformation of recombinant DNA from bacteria and a yeast

Applied and Environmental Microbiology, 1993
C. C. Tebbe, W. Vahjen
semanticscholar   +1 more source

The Vegan Villain Sets Out to The End of Summer: Functionalized Coatings as Biohybrid UV‐Sensors

Advanced Materials Interfaces, EarlyView.
This study introduces biohybrid coatings incorporating E. coli biomass expressing photoconvertible fluorescent proteins as UV‐A responsive elements. Upon irradiation at 400 nm, the coatings exhibit an irreversible fluorescence shift from green to red within 15 min. Notably, the photoconversion capability is retained after >1 year of storage.
Amelie Skopp, Matea Marosevic, Broder Rühmann, Volker Sieber   +3 more
wiley   +1 more source

Research progress on the diagnostic techniques and vaccine development of bovine herpesvirus types 1. [PDF]

Front Vet Sci
Zhang J, Cao J, Cao L, Zhang C, Gong L, Kang X, Li D, Zhang Y.   +7 more
europepmc   +1 more source

Characterization of The Electrical and Optical Properties of Ultrabithorax Fusion Fibers for Biosensing

Advanced Materials Technologies, EarlyView.
In this work, Ultrabithorax (Ubx) protein fusions with myoglobin, EGFP and mCherry are investigated and proposed for biosensing applications. For the first time, FRET calculations based on fluorescent lifetime measurements are presented for Ubx‐based protein fusions.
Karol Szuba‐Jablonski, A. Bernardus Mostert, Drew B. Riley, Kenith E. Meissner   +3 more
wiley   +1 more source

Oxford nanopore sequencing as a useful tool for investigating the population dynamics of invasive begomoviruses in Sicily. [PDF]

Microb Genom
Bertacca S, Rotunno S, Frascati F, Noris E, Accotto GP, Davino S, Miozzi L, Vaira AM.   +7 more
europepmc   +1 more source

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

Proceedings of the National Academy of Sciences of the United States of America, 1986
T. Fuerst, E. G. Niles, F. Studier, B. Moss   +3 more
semanticscholar   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Enhanced immunogenicity in mouse by recombinant BCG prime and protein boost based on latency antigen Rv1733c and/or reactivation antigen RpfE. [PDF]

BMC Infect Dis
Ashayeripanah M, Kazemi B, Saubi N, Joseph-Munne J, Eftekhar F.   +4 more
europepmc   +1 more source