Results 141 to 150 of about 315,433 (266)

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators. [PDF]

Cells
Muñoz López M, López-Gil JF, Ramírez de la Piscina Viúdez X, Baz-Valle E, Tornero Aguilera JF.   +4 more
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming

Angewandte Chemie, EarlyView.
RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh, Hansol Kang, Chaeri Kim, Jongmin Kim   +3 more
wiley   +2 more sources

Antibiotic resistance in <i>Aeromonas hydrophila</i> associated with exposure to subtherapeutic levels of oxytetracycline. [PDF]

Front Microbiol
Zhang J, Huang L, Zhong L, Wang Z, Schunter C, St-Hilaire S.   +5 more
europepmc   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Tn-seq of Thermus thermophilus Genome Reveals Unexpected Tolerance to Insertions in Bacterial Common Essential Genes. [PDF]

Microbiologyopen
Gómez-Campo CL, Gost M, de Sousa BFS, Álvarez L, Berenguer J, Redrejo-Rodríguez M, Mencía M.   +6 more
europepmc   +1 more source

Integrative utilization of genomic resources for improved phylogenetic resolution in Sonerileae (Melastomataceae)

American Journal of Botany, EarlyView.
Abstract Premise Advances in new next‐generation sequencing (NGS) methods have revolutionized phylogenetics, yet challenges remain in effectively utilizing data from a wide range of sources. A well‐resolved and broadly sampled phylogeny for Sonerileae, the second‐largest tribe in Melastomataceae, is still lacking, hindering our understanding of its ...
Luo Chen, Marie Claire Veranso‐Libalah, J. Peter Quakenbush, Ying Liu, Fabián A. Michelangeli, Diego F. Morales‐Briones, Gudrun Kadereit   +6 more
wiley   +1 more source

Observing intersubunit dynamics in single yeast ribosomes. [PDF]

Nucleic Acids Res
Das A, Grove AK, Ivanov AV, Wakabayashi H, Ermolenko DN.   +4 more
europepmc   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source