Results 21 to 30 of about 2,640,580 (326)

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging

Genome Research, 2019
The ribosomal DNA (rDNA) is the most evolutionarily conserved segment of the genome and gives origin to the nucleolus, an energy intensive nuclear organelle and major hub influencing myriad molecular processes from cellular metabolism to epigenetic ...
Meng Wang, B. Lemos
semanticscholar   +1 more source

Comparative analyses of classical phenotypic method and ribosomal RNA gene sequencing for identification of medically relevant Candida species

Memorias do Instituto Oswaldo Cruz, 2013
As the distribution of Candida species and their susceptibility to antifungal agents have changed, a new means of accurately and rapidly identifying these species is necessary for the successful early resolution of infection and the subsequent reduction ...
Constanza Giselle Taverna, María Eugenia Bosco-Borgeat, Omar Alejandro Murisengo, Graciela Davel, Mariana Côrtes Boité, Elisa Cupolillo, Cristina Elena Canteros   +6 more
doaj   +1 more source

Roles of ribosomal proteins in hematologic disorders and cancers: a review

Emergency and Critical Care Medicine, 2023
. Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation ...
Jie Wang, Feng Yan
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

RNase H enables efficient repair of R-loop induced DNA damage. [PDF]

, 2016
R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core   +1 more source

Genomic function during the lampbrush chromosome stage of amphibian oogenesis [PDF]

, 1966
Throughout its lengthy developmental history the disposition of the genetic material in the amphibian oocyte nucleus differs from that in other cell types.
Crippa, Marco, Davidson, Eric H., Kramer, Fred R., Mirsky, Alfred E.   +3 more
core   +1 more source

Organization and expression analysis of 5S and 45S ribosomal DNA clusters in autotetraploid Carassius auratus

BMC Ecology and Evolution, 2021
Background Autotetraploid Carassius auratus (4n = 200, RRRR) (abbreviated as 4nRR) is derived from whole genome duplication of Carassius auratus red var. (2n = 100, RR) (abbreviated as RCC).
Chun Zhao, Yuxin Zhang, Huan Qin, Chongqing Wang, Xu Huang, Li Yang, Tingting Yu, Xidan Xu, Xiang Luo, Qinbo Qin, Shaojun Liu   +10 more
doaj   +1 more source

Mild cognitive impairment is associated with low copy number of ribosomal genes in the genomes of elderly people

Frontiers in Genetics, 2022
Introduction: Mild cognitive impairments (MCI) accompanying aging are associated with oxidative stress. The ability of cells to respond to stress is determined by the protein synthesis level, which depends on the ribosomes number.
Natalia N. Veiko, Elizaveta S. Ershova, Elizaveta S. Ershova, Roman V. Veiko, Pavel E. Umriukhin, Pavel E. Umriukhin, Pavel E. Umriukhin, Marat V. Kurmyshev, Georg P. Kostyuk, Sergey I. Kutsev, Svetlana V. Kostyuk, Svetlana V. Kostyuk   +11 more
doaj   +1 more source

Utilization of Pyrosequencing to Monitor the Microbiome Dynamics of Probiotic Treated Poultry (Gallus gallus domesticus) during Downstream Poultry Processing [PDF]

, 2017
Antibiotic growth promoters that have been historically employed to control pathogens and increase the rate of animal development for human consumption are currently banned in many countries.
Bray, Joey, Clack, Beatrice, Guttala, Vamsy Priya, Medrano, Enrique G.   +3 more
core   +3 more sources

A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]

, 2009
BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Bull, TJ, Hermon-Taylor, J, Hinds, J, Linedale, R   +3 more
core   +3 more sources