Results 91 to 100 of about 31,740 (263)

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

SnRNA‐seq reveals cellular heterogeneity and proliferation mechanisms in limb venous malformations

Animal Models and Experimental Medicine, EarlyView.
To dissect the cellular heterogeneity and invasive mechanisms of limb venous malformations (VMs), this study first obtained tissue samples from four patients with VMs and four normal controls (NC). Single‐nucleus suspension was prepared, followed by transcriptome library construction and sequencing. After pretreatment, quality control, standardization,
Junjie Lin, Tingting Liu, Bin Fang, Xiaojuan Feng, Wenting Jiao, Changkuan Chen, Yaqing Ding, Gaozan Zhu, Wenqiu Wang, Wenbo Liu, Yuanqi Li, Shoufu Hou, Jianshe Wei, Junbo Qiao   +13 more
wiley   +1 more source

Molecular detection of parasites (Trematoda, Digenea: Bucephalidae and Monorchiidae) in the European flat oyster Ostrea edulis (Mollusca: Bivalvia)

The European Zoological Journal, 2018
Members of the globally distributed bivalve family Ostreidae (oysters) have a significant role in marine ecosystems and include species of high economic importance. In this work, we report the occurrence of digenean parasites of the families Bucephalidae
E. Mancini, G. Furfaro, M. Cervelli, A. Di Giulio, M. Oliverio, D. Salvi, P. Mariottini   +6 more
doaj   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Banana Classification Using Sanger Sequencing of the Ribosomal DNA Internal Transcribed Spacer (ITS) Region

Plants
Banana (Musa spp.) is one of the most economically important horticultural crops. There are many types of banana, with differing ploidy (usually diploid, triploid, or tetraploid) and genome types (most containing the A or/and B genome).
Hongyun Zeng, Bingzhi Huang, Linbing Xu, Yuanli Wu   +3 more
doaj   +1 more source

To the Question of Rhododendron L. Genus Phylogeny Based on ITS1-ITS2 Spacers Sequence Studies [PDF]

Сибирский лесной журнал, 2014
The first and second internal transcribed spacer (ITS1 and ITS2) regions of the ribosomal DNA and 5.8S rRNA gene from Rhododendron L. were analysed.
T. V. Baranova, R. N. Kalendar
doaj  

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, EarlyView.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source