Results 201 to 210 of about 578,618 (302)

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

A Comparative Study for the Incorporation of 8-oxo-dATP in DNA by Human DNA Polymerases. [PDF]

Int J Mol Sci
Kruchinin AA, Kamzeeva PN, Baranov MS, Belova YG, Boldinova EO, Baranovskiy AG, Tahirov TH, Aralov AV, Makarova AV.   +8 more
europepmc   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Azure A Dye Interaction with Double-Stranded DNA Can Be Modulated by the Ionic Strength: Choosing the Binding Mode. [PDF]

ACS Omega
de Rezende AGS, Portilho EA, Batista JAD, Rocha MS.   +3 more
europepmc   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source

PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development. [PDF]

Commun Biol
Fréreux C, Karam JAQ, Howley BV, Granger B, Chakraborty P, Vaena S, Romeo M, Dalton AC, Mohanty BK, Mehrotra S, Howe PH.   +10 more
europepmc   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

YY1 Interacts with Promoter R-Loops to Regulate Transcription. [PDF]

J Am Chem Soc
He X, Yuan J, Li L, Gao Z, Wang Y.
europepmc   +1 more source

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Advanced Materials, EarlyView.
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed, Yu‐Hsuan Peng, Azra Atabay, Krishna Gupta, Toni Müller, Carolin Fischer, Ilka M. Hermes, Jens‐Uwe Sommer, Michael Lang, Elisha Krieg   +9 more
wiley   +1 more source

APE1 Activity is Controlled by Non-G-Quadruplex Conformations in Single- and Double-Stranded G-Quadruplex Constructs. [PDF]

Chemistry
Trabucco BL, Fleming AM, Burrows CJ.
europepmc   +1 more source