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Chinese Giant Salamander Iridovirus 025L Is a Viral Essential Gene
Viruses, 2023 Ranavirus is a large nucleocytoplasmic DNA virus. Chinese giant salamander iridovirus (CGSIV) belongs to the ranavirus genus, and its replication involves a series of essential viral genes.
Zijing Liu +7 more
doaj +1 more source
HSV-1 not only in human vestibular ganglia but also in the vestibular labyrinth [PDF]
, 2001 Reactivation of herpes simplex virus type 1 (HSV-1) in the vestibular ganglion (VG) is the suspected cause of vestibular neuritis (VN). Recent studies reported the presence of HSV-1 DNA not only in human VGs but also in vestibular nuclei, a finding that ...
Arbusow, Viktor +4 more
core +1 more source
Designer DNA nanostructures for viral inhibition [PDF]
Nature Protocols, 2022 Emerging viral diseases can substantially threaten national and global public health. Central to our ability to successfully tackle these diseases is the need to quickly detect the causative virus and neutralize it efficiently. Here we present the rational design of DNA nanostructures to inhibit dengue virus infection.
Shaokang Ren +8 more
openaire +2 more sources
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells [PDF]
, 2015 The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family.
Almohammad, Rajei +8 more
core +2 more sources
Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA. [PDF]
PLoS Pathogens, 2013 Replication foci are generated by many viruses to concentrate and localize viral DNA synthesis to specific regions of the cell. Expression of the HPV16 E1 and E2 replication proteins in keratinocytes results in nuclear foci that recruit proteins ...
Nozomi Sakakibara +7 more
doaj +1 more source
Single virus fingerprinting by widefield interferometric defocus-enhanced mid-infrared photothermal microscopy [PDF]
arXiv, 2022 Clinical identification and fundamental study of viruses rely on the detection of viral proteins or viral nucleic acids. Yet, amplification-based and antigen-based methods are not able to provide precise compositional information of individual virions due to small particle size and low-abundance chemical contents (e.g., ~ 5000 proteins in a vesicular ...
arxiv
Inhibition of DNA ejection from bacteriophage by Mg+2 counterions [PDF]
J. Chem. Phys. 134 (2011) 125104, 2008 The problem of inhibiting viral DNA ejection from bacteriophages by multivalent counterions, specifically Mg$^{+2}$ counterions, is studied. Experimentally, it is known that MgSO$_4$ salt has a strong and non-monotonic effect on the amount of DNA ejected. There exists an optimal concentration at which the minimum amount of DNA is ejected from the virus.
arxiv +1 more source
Inhibition of histone methyltransferase SETD8 represses DNA virus replication
Cell Insight, 2022 Multiple diseases, such as cancer and neural degeneration diseases, are related with the latent infection of DNA viruses. However, it is still difficult to clean up the latent DNA viruses and new anti-viral strategies are critical for disease treatment ...
Lin Chen +6 more
doaj
The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
core +1 more source