Replication-Uncoupled Histone Deposition during Adenovirus DNA Replication [PDF]
, 2012 In infected cells, the chromatin structure of the adenovirus genome DNA plays critical roles in its genome functions. Previously, we reported that in early phases of infection, incoming viral DNA is associated with both viral core protein VII and ...
Komatsu Tetsuro +3 more
core +1 more source
DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
iScienceSummary: To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription.
Dayana B. Hristova +6 more
doaj +1 more source
The role of unintegrated DNA in HIV infection
Retrovirology, 2011 Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various unintegrated viral DNA forms exist in abundance. Though linear viral cDNA is the precursor to an
Wainberg Mark A, Sloan Richard D
doaj +1 more source
Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung
British Journal of Cancer, 2016 Background:Although ∼20% of human cancers are caused by microorganisms, only suspicion exists for a microbial cause of lung cancer. Potential infectious agents were investigated in non-small cell lung cancer (NSCLC) and non-neoplastic lung.Methods ...
L. Robinson +7 more
semanticscholar +1 more source
Viral oncoproteins target the DNA methyltransferases [PDF]
Oncogene, 2006 Small DNA tumour viruses have evolved a number of mechanisms to drive nondividing cells into S phase. Virally encoded oncoproteins such as adenovirus E1A and human papillomavirus (HPV) E7 can bind an array of cellular proteins to override proliferation arrest. The DNA methyltransferase Dnmt1 is the major mammalian enzyme responsible for maintaining CpG
Burgers, T +7 more
openaire +3 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Cytoplasmic DNA in the unfertilized sea urchin egg: Physical properties of circular mitochondrial DNA and the occurrence of catenated forms [PDF]
, 1968 The mitochondrial DNA in the unfertilized egg of the sea urchin Lytechinus pictus is present in an amount approximately seven times that of the haploid nuclear DNA.(1) The mitochondrial DNA has a higher buoyant density than the nuclear DNA and consists ...
Blair, Donald G. +3 more
core
Search for virus specific DNA sequences and viral particles in mitochondria of avian leukemic myeloblasts [PDF]
, 1977 The intracellular localization of the avian myeloblastosis virus (AMV) genome was studied. Nuclear and mitochondrial DNAs from myeloblasts were examined by hybridization with 32P labeled AMV-RNA of high molecular weight for the presence of virus specific
Oda, Takuzo, Ogura, Hajime
core +1 more source
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
Immunity & Ageing, 2019 Background T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood.
Yingjie Ji +15 more
doaj +1 more source
Preparation of Viral DNA from Nucleocapsids [PDF]
Journal of Visualized Experiments, 2011 Viruses are obligate cellular parasites, and thus the study of their DNA requires isolating viral material away from host cell contaminants and DNA. Several downstream applications require large quantities of pure viral DNA, which is provided by this protocol.
Moriah L, Szpara +2 more
openaire +2 more sources