Results 11 to 20 of about 3,377 (106)
Family Process, Volume 62, Issue 2, Page 818-834, June 2023., 2023 Abstract The accelerated pace of biological aging predicts mortality and morbidity later in life. The current study examines whether a change in supportive couple functioning buffers accelerated aging associated with stressful community environments among Black Americans who live in rural, Southern, disadvantaged neighborhoods.
Man‐Kit Lei, Steven R. H. Beach
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Journal of Diabetes, Volume 15, Issue 4, Page 349-361, April 2023., 2023 Highlights This is the first cross‐sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high‐risk Chinese population. Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m6A‐related genes could contribute to the occurrence of T2DM.
Xiaoying Wu +11 more
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Journal of Diabetes, Volume 14, Issue 2, Page 97-103, February 2022., 2022 Highlights Vitamin D receptor (VDR) methylation attenuates the association between physical activity and type 2 diabetes mellitus (T2DM). The methylation status of the VDR promoter is associated with the secretion and sensitivity of insulin. A high physical activity level is associated with a decreased risk of T2DM compared to a low physical activity ...
Songcheng Yu +7 more
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Veterinary Dermatology, Volume 32, Issue 6, Page 654-663, December 2021., 2021 Background Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro‐organisms. Hypothesis/Objectives Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S.
Lluís Ferrer +13 more
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
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Zhongguo shiyan zhenduanxue, 2020 DNA启动子或编码区CpG岛甲基化可通过转录抑制途径参与恶性肿瘤的发生和化疗药的耐药[1]。胞嘧啶5’位点甲基化(5-methylcytosine,5mc)是恶性肿瘤中常见的DNA甲基化位点[2]。5mc的形成是一个可逆的过程,研究显示TERT家族蛋白可将5mc进一步氧化为5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hmc),从而进入胸腺DNA合成途径[3]。恶性肿瘤,包括淋巴瘤中5hmC表达缺失预后差[4-6],提示监测5hmc表达水平有助于判断预后和疗效评估。
王学菊 +3 more
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Zhejiang Daxue xuebao. Lixue ban, 2007 以黄瓜种子为材料，采用甲硫氨酸(Methionine，Met)浸种的方法，研究了不同浓度Met对黄瓜种子萌发、幼苗生长及离体子叶成花的影响.结果发现：(1)10-4 M Met处理3 h显著促进苗的生长而10-5 M Met浸种处理则有利于子叶的生长；(2)10-5 M Met浸种处理显著促进离体子叶成花；（3）离体子叶培养物的花芽分化力与子叶离体前的子叶/苗的鲜重比呈显著的正相关性 ...
WANGShou-feng(王首锋) +3 more
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MLXIPL、PMVK、TRIB3基因启动子区甲基化检测方法的建立
Zhongguo shiyan zhenduanxue, 2010 目的建立基因MLXIPL、PMVK、TRIB3启动子区DNA甲基化检测的方法。方法用亚硫酸氢钠和对苯二酚处理外周血细胞基因组DNA标本,以修饰后的DNA标本为模板,每个基因分别用内外侧两套不同的引物对启动子区进行巢式扩增。PCR产物进一步克隆、测序。结果测序结果表明,MLXIPL、PMVK、TRIB3启动子区基因中的非甲基化的C碱基转变为T碱基,而CpG岛被甲基化的C碱基则不改变。结论成功地建立了MLXIPL、PMVK、TRIB3基因甲基化检测的方法,为探索基因启动子区甲基化与疾病的关系做出了铺垫。
钱冉, 郑芳, 郭书忍, 杨娜
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NSCLC组织中MGMT过甲基化状况与临床病理特征的关系探讨
Zhongguo shiyan zhenduanxue, 2011 目的探讨非小细胞肺癌（NSCLC）组织中DNA修复酶O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）过甲基化状况与临床病理特征的关系。方法以2006年3月到2009年7月在河南省胸科医院胸外科手术治疗的77例NSCLC患者作为研究对象,另外选取20例肺良性病变患者作为对照组,采用甲基化特异性PCR（MSP）检测两组病例肺部病变组织中MGMT的甲基化状况。结果研究组有26例出现MGMT基因甲基化,发生率为33.8%,对照组无1例出现MGMT基因甲基化,组间比较差异有统计学意义 ...
亢春彦 +4 more
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白血病患者ID4、WT1、GLIPR1基因启动子区异常甲基化及mRNA表达的研究
Zhongguo shiyan zhenduanxue, 2019 DNA甲基化（methylation）作为最早发现的修饰途径一直属于生命科学的前沿课题之一,其能引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变,从而控制基因表达[1]。研究显示[2]:白血病抑癌基因启动子异常甲基化与白血病的发病机制密切相关,抑癌基因启动子高甲基化抑制相关mRNA的表达水平可能为白血病发病的重要分子机制。本研究采用甲基化特异性PCR（MS-PCR）及实时荧光定量RT-PCR（RTQPCR）对ID4、WT1 ...
崔桂荣, 李焱, 贾振薇, 张金华
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