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Family Process, Volume 62, Issue 2, Page 818-834, June 2023., 2023 Abstract The accelerated pace of biological aging predicts mortality and morbidity later in life. The current study examines whether a change in supportive couple functioning buffers accelerated aging associated with stressful community environments among Black Americans who live in rural, Southern, disadvantaged neighborhoods.
Man‐Kit Lei, Steven R. H. Beach
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Journal of Diabetes, Volume 15, Issue 4, Page 349-361, April 2023., 2023 Highlights This is the first cross‐sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high‐risk Chinese population. Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m6A‐related genes could contribute to the occurrence of T2DM.
Xiaoying Wu +11 more
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Journal of Diabetes, Volume 14, Issue 2, Page 97-103, February 2022., 2022 Highlights Vitamin D receptor (VDR) methylation attenuates the association between physical activity and type 2 diabetes mellitus (T2DM). The methylation status of the VDR promoter is associated with the secretion and sensitivity of insulin. A high physical activity level is associated with a decreased risk of T2DM compared to a low physical activity ...
Songcheng Yu +7 more
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Veterinary Dermatology, Volume 32, Issue 6, Page 654-663, December 2021., 2021 Background Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro‐organisms. Hypothesis/Objectives Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S.
Lluís Ferrer +13 more
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DNA甲基化与2型糖尿病的相关性研究进展 Progress of the Relationship between DNA Methylation and Type 2 Diabetes
Zhongguo cuzhong zazhi, 2022 2型糖尿病是缺血性卒中最常见的危险因素之一，其发生、发展的机制尚未阐明。近年来多项研究发现，表观遗传学可以解释部分2型糖尿病相关风险。表观遗传学包括DNA甲基化、组蛋白修饰、染色质重塑、非编码RNA等，其中DNA甲基化是表观遗传学的重要组成部分，也是研究最早最广泛的机制。本文介绍了DNA甲基化在2型糖尿病相关的病理生理机制、环境因素、危险因素及并发症等方面的研究进展，探讨了DNA甲基化用于2型糖尿病预测及诊疗的临床前景，提出了通过研究DNA甲基化促进缺血性卒中一级及二级预防的可能 ...
崔凌云, 仇鑫, 周宏宇, 李子孝, 王拥军
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DNA甲基化与高血压的相关性研究进展 Progress of the Relationship between DNA Methylation and Hypertension
Zhongguo cuzhong zazhi, 2023 高血压是缺血性卒中最常见的可调节危险因素之一，作为一种多病因、高度异质性的疾病，环境、遗传因素在高血压的发生、发展过程中发挥着重要作用。基因与环境之间的相互作用，也就是表观遗传修饰可能介导遗传因素、环境因素和缺血性卒中之间的关系，但具体机制仍不明确。表观遗传修饰包括DNA甲基化、组蛋白修饰、染色质重塑等，其中DNA甲基化是表观遗传的重要组成部分，也是研究相对成熟的机制。DNA甲基化可以调节基因的表达，同时也受环境因素的影响。本文介绍了DNA甲基化在高血压相关病理生理机制 ...
侯叶叶, 周宏宇, 李子孝
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Zhongguo cuzhong zazhi, 2023 缺血性卒中由多种环境因素和遗传风险因素共同决定。DNA甲基化作为一种重要的表观遗传学调控机制，可能是缺血性卒中的可遗传危险因素，对缺血性卒中的发生、发展过程产生潜在影响。缺血性卒中不同病因亚型存在特征性候选基因DNA甲基化水平改变，这对探究不同病因亚型的病理生理学过程具有重要价值。DNA甲基化是动态、可逆的表观遗传学改变，其模式可随疾病发生、发展的不同时期发生显著变化，提示DNA甲基化可作为缺血性卒中及其亚型的潜在生物标志物和治疗靶点。本文就DNA甲基化与非大动脉粥样硬化型（心源性栓塞型、小动脉闭塞型 ...
姜晓晴, 瓮佳旭, 周宏宇, 李子孝, 王拥军
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DNA甲基化与高同型半胱氨酸血症 DNA Methylation and Hyperhomocysteinemia
Zhongguo cuzhong zazhi, 2023 DNA甲基化是一种调控基因表达的表观遗传机制，由Hcy代谢相关底物S-腺苷同型半胱氨酸（S-adenosyl-L-homocysteine，SAH）依赖性的DNA甲基转移酶（DNA methyltransferases，DNMTs）催化，对维持细胞稳态至关重要。多项研究表明，高同型半胱氨酸血症（hyperhomocysteinemia，HHcy）可能通过调节甲硫氨酸-同型半胱氨酸循环（methionine-homocysteine cycle，M-H cycle）调控DNA甲基化状态 ...
瓮佳旭, 周宏宇, 李子孝
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Zhongguo cuzhong zazhi, 2022 DNA甲基化与卒中预后相关。脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）基因及血清素再摄取转运体编码基因——溶质载体家族6成员4（solute carrier family 6，member 4，SLC6A4）基因表达均受到DNA甲基化调控，可能通过多种途径在改善卒中患者的临床预后方面发挥重要作用。BDNF基因启动子区域的甲基化会导致BDNF的合成减少，从而通过抑制细胞黏附、细胞增殖、血管生成等多种机制影响卒中后的功能恢复 ...
闫然, 闵妍, 全柯华, 李子孝
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DNA甲基化与高脂血症的关系研究进展 Progress of the Relationship between DNA Methylation and Hyperlipidemia
Zhongguo cuzhong zazhi, 2023 高脂血症是心血管疾病的主要危险因素之一，且是可遗传、可干预的因素。较多研究发现，DNA甲基化修饰与血脂水平之间具有相关性，目前发现涉及的基因主要有肉碱棕榈酰转移酶1A（carnitine palmitoyl transferase 1 A，CPT1A）基因、三磷酸腺苷结合盒转运体G1（adenosine triphosphate binding cassette transporter G1，ABCG1）基因、固醇调控元件结合蛋白1（sterol regulatory element-binding ...
韩颖, 周宏宇, 李子孝
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