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DNA甲基化与脑血管病 DNA Methylation and Cerebrovascular Diseases
Zhongguo cuzhong zazhi, 2022 仇鑫，李子孝
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Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨癌胚抗原(CEA)表达水平不同的肺癌细胞株在转录因子水平有无差异。【方法】利用电泳迁移分析 法(EMSA)检测这些细胞株与CEA 启动子阳性足迹区探针结合的DNA 结合蛋白。维甲酸(RA)诱导分化A549 细胞, 检测诱 导前后转录因子的变化。【结果】CEA 水平高的细胞DNA 结合蛋白的条带信号强, CEA 水平低的细胞DNA 结合蛋白的条带 信号弱, CEA 阴性细胞可见到较弱的DNA 结合蛋白信号。结合条带信号在诱导后细胞组明显减弱。【结论】CEA 基因特异 ...
徐 平, 李 芳
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Zhongshan Daxue xuebao. Yixue kexue ban, 1995 临床标本进行ＤＮＡ抽提后，用聚合酶链反应（ＰＣＲ）将具有６２３个ｂｐ的耐甲氧苯青霉素金黄色葡萄球菌（ＭＲＳＡ）的ｍｅｃＡ基因扩增，经琼脂糖电泳及ＤＮＡ印迹杂文（ｓｏｕｔｈｅｒｎｂｌｏｔｈｙｂｒｉｄｉｚａｔｉｏｎ），并用ＥＣＬ３’寡核苷酸标记增强化学发光进行检测，其结果与ＭＲＳＡ常规培养方法作比较。结果显示，７３份临床标本中，１５份常规培养法ＭＲＳＡ和ＰＣＲ法ｍｅｃＡ基因均为阳性，另１份ｍｅｃＡ基因扩增阳性的标本，常规培养ＭＲＳＡ为阴性。作者认为，由于ＰＣＲ对检测ＭＲＳＡ的ｍｅｃＡ基因具有快速 ...
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[Research Progress in the Mechanisms of Acupuncture in Regulating DNA Methylation]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanGao S +5 more
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[Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanLiu S +15 more
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Clinical applications of abnormal DNA methylation in chronic myeloid leukemia. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanZhou L, Yin X.
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[A two-site combined prediction model based on HOXA9 DNA methylation for early screening of risks of meningioma progression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoTan R, Bao X, Han L, Li Z, Tian N.
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A comprehensive guide to genome<b>-</b>wide DNA methylation research in neuropsychiatric disorders and its implications for deep<b>-</b>space environments. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanXu S, Min S, Gu H, Wang X, Chen C.
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Zhongshan Daxue xuebao. Yixue kexue ban糖尿病肾病（DKD）是指由糖尿病导致的慢性肾脏疾病，受遗传和环境因素及其相互作用的影响，是慢性肾脏病和终末期肾病的主要病因。小檗碱（BBR）是一种天然的异喹啉生物碱。近年来研究发现，BBR具有降血糖、降血脂、抗氧化、抗炎及抗纤维化作用，可以有效改善DKD的肾脏损害，其作用机制可能包括：改善糖脂代谢、减轻氧化应激、减轻炎症反应、改善肾脏纤维化、调控DNA甲基化、改善线粒体功能、调节肠道菌群，改善肠道代谢及清除功能。本文系统性综述了BBR治疗DKD的作用机制的研究现状 ...
曲柄衡, 童晓鹏
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