A comprehensive guide to genome<b>-</b>wide DNA methylation research in neuropsychiatric disorders and its implications for deep<b>-</b>space environments. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanXu S, Min S, Gu H, Wang X, Chen C.
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[Neutrophil-derived Microvesicles Regulate DNA Methylation of the <i>LINE1</i> Gene in Human Fibroblast-like Synoviocytes]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanZhao Z +8 more
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[The Clinical Application and Development of Tumor Biomarkers in China]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanWang C.
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[A real-world study of clinical cure in children with HBeAg-positive chronic hepatitis B from the Guangxi region]. [PDF]
Zhonghua Gan Zang Bing Za ZhiLyu RY +7 more
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[Occurrence characteristics， neurotoxicity risk， and potential mechanisms of traditional phthalate esters and novel alternatives in indoor dust]. [PDF]
Se PuLi W, Gao K, Hua K, Wang L, Wei W, Lu L.
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Zhongshan Daxue xuebao. Yixue kexue ban糖尿病肾病（DKD）是指由糖尿病导致的慢性肾脏疾病，受遗传和环境因素及其相互作用的影响，是慢性肾脏病和终末期肾病的主要病因。小檗碱（BBR）是一种天然的异喹啉生物碱。近年来研究发现，BBR具有降血糖、降血脂、抗氧化、抗炎及抗纤维化作用，可以有效改善DKD的肾脏损害，其作用机制可能包括：改善糖脂代谢、减轻氧化应激、减轻炎症反应、改善肾脏纤维化、调控DNA甲基化、改善线粒体功能、调节肠道菌群，改善肠道代谢及清除功能。本文系统性综述了BBR治疗DKD的作用机制的研究现状 ...
曲柄衡, 童晓鹏
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[Identification of SORD as A Key Gene Mediating Osimertinib Primary Resistance in EGFR-Mutant Lung Adenocarcinoma via Machine Learning and Methylomics]. [PDF]
Zhongguo Fei Ai Za ZhiLiang G +8 more
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[Research progress on cellular senescence and liver diseases]. [PDF]
Zhonghua Gan Zang Bing Za ZhiZhang LT, Hu JM, Wang JW, Li H, Qin YJ.
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[Progress in regulating stem cell functions for repair and regeneration of craniomaxillofacial tissues]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanZhang H, Yang F, Yang R.
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Zhongshan Daxue xuebao. Yixue kexue ban糖尿病（DM）患者长期高血糖所致骨质疏松及骨愈合延迟等骨骼并发症已成为显著降低其生活质量的临床难题，其核心机制与脂肪干细胞（ADSCs）成骨分化能力受损密切相关。在骨组织工程中，ADSCs因取材微创、增殖迅速及多向分化能力被视为骨缺损修复的种子细胞，但DM病理环境显著抑制了ADSCs的成骨潜能，进而影响了糖尿病骨病的治疗效率。因此，探索高糖环境下ADSCs成骨能力障碍的深层机制对优化糖尿病骨病的治疗策略具有重要意义。本文系统回顾并总结了高糖环境中ADSCs迁移能力下降、增殖活性降低 ...
韩芳, 田峻
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