Results 181 to 190 of about 5,163,408 (306)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins. [PDF]

Nucleic Acids Res, 2023
Wang X, Bigman LS, Greenblatt HM, Yu B, Levy Y, Iwahara J.   +5 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

iDLDDG: predicting protein stability changes from missense mutations in DNA-binding proteins using integrated deep learning features. [PDF]

Brief Bioinform
Yu X, Ge F, Yu DJ, Deng Z.
europepmc   +1 more source

Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins. [PDF]

Nat Commun, 2023
Elliott K, Singh VK, Boström M, Larsson E.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. [PDF]

Proc Natl Acad Sci U S A, 2023
Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning. [PDF]

Commun Biol
Tahmid MT, Hasan AKMM, Bayzid MS.
europepmc   +1 more source

Hybrid_DBP: Prediction of DNA-binding proteins using hybrid features and convolutional neural networks. [PDF]

Front Pharmacol, 2022
Yu S, Peng D, Zhu W, Liao B, Wang P, Yang D, Wu F.   +6 more
europepmc   +1 more source