Results 171 to 180 of about 5,163,408 (306)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ETfinder: harnessing conserved C-terminal tails of single-stranded DNA-binding proteins for mining and engineering RecET systems in non-model microbial chassis. [PDF]

Nucleic Acids Res
Lv D, Liang M, Gu Y, Zhu X, Wang H, Xia M, Hao J, Li Y, Wang W, Bai L, Cheng J, Zhang L, Tan GY.   +12 more
europepmc   +1 more source

Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). [PDF]

Nucleic Acids Res, 2023
Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A Bifunctional Antibody Conjugate for Marking the Location of DNA Binding Proteins on DNA Fibers. [PDF]

ACS Omega
Pokharel D, Shaik A, Gali H, Ling C, Bellani MA, Seidman MM.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

In silico identification of archaeal DNA-binding proteins. [PDF]

Bioinformatics
Donvil L, Housmans JAJ, Peeters E, Vranken W, Orlando G.   +4 more
europepmc   +1 more source

Single-molecule characterization of target search dynamics of DNA-binding proteins in DNA-condensed droplets. [PDF]

Nucleic Acids Res, 2023
Kamagata K, Kusano R, Kanbayashi S, Banerjee T, Takahashi H.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex. [PDF]

Mol Cell
Wang X, Aboreden NG, Cai Y, Lam JC, Henderson KA, Xiang J, Giardine BM, Hardison RC, Keller CA, Nagarajan L, Brandt SJ, Blobel GA.   +11 more
europepmc   +1 more source