Results 191 to 200 of about 5,403,999 (308)

iDLDDG: predicting protein stability changes from missense mutations in DNA-binding proteins using integrated deep learning features. [PDF]

Brief Bioinform
Yu X, Ge F, Yu DJ, Deng Z.
europepmc   +1 more source

Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins. [PDF]

Nat Commun, 2023
Elliott K, Singh VK, Boström M, Larsson E.   +3 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. [PDF]

Proc Natl Acad Sci U S A, 2023
Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR.   +4 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning. [PDF]

Commun Biol
Tahmid MT, Hasan AKMM, Bayzid MS.
europepmc   +1 more source

Hybrid_DBP: Prediction of DNA-binding proteins using hybrid features and convolutional neural networks. [PDF]

Front Pharmacol, 2022
Yu S, Peng D, Zhu W, Liao B, Wang P, Yang D, Wu F.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Single-molecule fluorescence reveals the DNA unwinding mechanism of mitochondrial helicase TWINKLE and its interplay with single-stranded DNA-binding proteins. [PDF]

Nucleic Acids Res
Wang HY, Lee YY, Chien PJ, Tsai WA, Sun PJ, Wang LT, Wu CC, Fan HF.   +7 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source