Results 151 to 160 of about 416,069 (337)
A novel mechanism for direct real-time polymerase chain reaction that does not require DNA isolation from prokaryotic cells [PDF]
, 2016 Takashi Soejima +2 more
openalex +1 more source
Integrative Approaches for DNA Sequence‐Controlled Functional Materials
Advanced Functional Materials, EarlyView.DNA is emerging as a programmable building block for functional materials with applications in biomimicry, biochemical, and mechanical information processing. The integration of simulations, experiments, and machine learning is explored as a means to bridge DNA sequences with macroscopic material properties, highlighting current advances and providing ...
Aaron Gadzekpo +4 more
wiley +1 more source
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
Nature CommunicationsDNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target in HDR-deficient cancers.
Fumiaki Ito +13 more
doaj +1 more source
In vitro transcription of the avian retrovirus genome by the alpha form of the viral RNA-directed DNA polymerase [PDF]
, 1977 Marc S. Collett +2 more
openalex +1 more source
Advanced Functional Materials, EarlyView.This review highlights how machine learning (ML) algorithms are employed to enhance sensor performance, focusing on gas and physical sensors such as haptic and strain devices. By addressing current bottlenecks and enabling simultaneous improvement of multiple metrics, these approaches pave the way toward next‐generation, real‐world sensor applications.
Kichul Lee +17 more
wiley +1 more source
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
Advanced Functional Materials, EarlyView.FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
Nature CommunicationsHistone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitment of the DNA ...
Diego Dibitetto +26 more
doaj +1 more source