Results 181 to 190 of about 408,006 (311)

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Directed Evolution of T7 RNA Polymerase Minimizes dsRNA By-product and Enables High-Fidelity mRNA Synthesis for Demanding Therapeutic Applications. [PDF]

Research (Wash D C)
Qin W, Nie T, Hei M, Li L, Pan Y, Luo M, Yang GY.   +6 more
europepmc   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Enhancement of prime editing by recruiting engineered or evolved components and implementing novel strategies. [PDF]

Biochem Biophys Rep
Arabi M, Alizadeh F, Yousefi Y, Afarandeh H, Mozaffari Jovin S, Eslahi A, Mojarrad M.   +6 more
europepmc   +1 more source

The role of dinB in UV survival and UV-induced mutagenesis in Escherichia coli [PDF]

, 2009
Lee, Mei-Chong Wendy
core   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Model organisms in POLG-related disorders: insights from yeast to multicellular systems. [PDF]

Cell Death Dis
Casas RB, Risato G, Zuppardo A, Viscomi C, Argenton F, Doimo M, Facchinello N, Tiso N.   +7 more
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Epigenetic odyssey to decrypt the hidden code for sustainable brassica production: enhancing yield, stress resilience and nutritional quality. [PDF]

Front Plant Sci
Maithreyi RS, Preet S, Tanwar K, Chakraborty P, Gupta I, Verma R, Bharti J, Thangaraj A, Kaul R, Kaul T.   +9 more
europepmc   +1 more source

Iwr1 directs RNA polymerase II nuclear import [PDF]

, 2011
Czeko, Elmar
core