Results 11 to 20 of about 3,048,093 (298)

Changes in the nuclear distribution of DNA polymerase alpha and PCNA/cyclin during the progress of the cell cycle, in a cell-free extract of Xenopus eggs [PDF]

, 1989
The nuclear distribution of DNA polymerase alpha and PCNA/cyclin in embryonic nuclei has been investigated, in a cell-free extract of Xenopus eggs that recapitulates a basic cell-cycle in vitro, by indirect immunofluorescence microscopy.
Kill, IR, Hutchison, C
core   +6 more sources

dnaX36 mutator of Escherichia coli: effects of the tau subunit of the DNA polymerase III holoenzyme on chromosomal DNA replication fidelity. [PDF]

, 2011
The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded τ subunit of the DNA polymerase III (Pol III) holoenzyme.
Jonczyk, Piotr, Roel M. Schaaper, Gawel, Damian, Piotr Jonczyk, Damian Gawel, Fijalkowska, Iwona J., Schaaper, Roel, Iwona J. Fijalkowska   +7 more
core   +2 more sources

Discovery of cyanophage genomes which contain mitochondrial DNA polymerase [PDF]

, 2011
DNA polymerase γ is a family A DNA polymerase responsible for the replication of mitochondrial DNA in eukaryotes. The origins of DNA polymerase γ have remained elusive because it is not present in any known bacterium, though it has been hypothesized that
Whitworth, Anna L., Holmes, Antony B., Mohr, Remus, Hess, Wolfgang R., Nicholas H. Mann, David J. Scanlan, Remus Mohr, Scanlan, David J., Antony B. Holmes, Anthony W. Larkum, Martha R. J. Clokie, Clokie, Martha R. J., Anna L. Whitworth, Yi-Wah Chan, Millard, Andrew D., Wolfgang R. Hess, Mann, Nicholas H., Andrew D. Millard, Chan, Yi-Wah, Larkum, Anthony W. D.   +19 more
core   +1 more source

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase {alpha} [PDF]

, 2006
In order to further understand how DNA polymerases discriminate against incorrect dNTPs, we synthesized two sets of dNTP analogues and tested them as substrates for DNA polymerase a (pol alpha) and Klenow fragment (exo-) of DNA polymerase I (Escherichia ...
Beckman, Jeff, Halcomb, Randall L., Kincaid, Kristi, Zivkovic, Aleksandra, Kuchta, Robert D., Engels, Joachim W. (Prof. Dr.)   +5 more
core   +1 more source

REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo [PDF]

, 2008
Exposure to ultraviolet light induces a number of forms of damage in DNA, of which (6-4) photoproducts present the most formidable challenge to DNA replication.
Marcus, AP, Iwai, S, Szüts, D, Himoto, M, Sale, JE   +4 more
core   +1 more source

Dual role of φ29 DNA polymerase Lys529 in stabilisation of the DNA priming-terminus and the terminal protein-priming residue at the polymerisation site.

PLoS ONE, 2013
Resolution of the crystallographic structure of φ29 DNA polymerase binary and ternary complexes showed that residue Lys529, located at the C-terminus of the palm subdomain, establishes contacts with the 3' terminal phosphodiester bond.
Alicia del Prado, José M Lázaro, Laurentino Villar, Margarita Salas, Miguel de Vega   +4 more
doaj   +1 more source

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

HemaSphere, 2022
Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using
Miriam Rehberger, Jonas A. Schäfer, Anna-Maria Krampitz, Anne Catherine Bretz, Lukas Jost, Torsten Haferlach, Thorsten Stiewe, Andreas Neubauer   +7 more
doaj   +1 more source

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. [PDF]

PLoS Genetics, 2009
Polymerase micro (Polmicro) is an error-prone, DNA-directed DNA polymerase that participates in non-homologous end-joining (NHEJ) repair. In vivo, Polmicro deficiency results in impaired Vkappa-Jkappa recombination and altered somatic hypermutation and ...
Daniel Lucas, Beatriz Escudero, José Manuel Ligos, Jose Carlos Segovia, Juan Camilo Estrada, Gloria Terrados, Luis Blanco, Enrique Samper, Antonio Bernad   +8 more
doaj   +1 more source

Endonuclease activity of purified RNA-directed DNA polymerase from avian myeloblastosis virus.

Journal of Biological Chemistry, 1979
Highly purified preparations of RNA-directed DNA polymerase from avian myeloblastosis virus (AMV) contain a Mn2+-activated endonuclease activity capable of nicking supercoiled DNA.
M. Golomb, Duane P. Grandgenett
semanticscholar   +1 more source