Results 241 to 250 of about 693,481 (331)
DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides [PDF]
, 2014 Roberto Laos +2 more
openalex +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Synthesis and Incorporation of a pH-Responsive Nucleoside Into DNA Sequences. [PDF]
ChembiochemOgel E, Becker S.
europepmc +1 more source
Advanced Science, EarlyView.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair. [PDF]
Proc Natl Acad Sci U S ALi Y +6 more
europepmc +1 more source
Advanced Science, EarlyView.Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong +9 more
wiley +1 more source
Engineered chimeric T7 RNA polymerase improves salt tolerance and reduces dsRNA impurity generation during in vitro transcription of mRNA. [PDF]
Nucleic Acids ResSanjeev A +4 more
europepmc +1 more source
Marker rescue of endogenous cellular genetic information related to the avian leukosis virus gene encoding RNA-directed DNA polymerase [PDF]
, 1978 Geoffrey M. Cooper
openalex +1 more source
Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity
Advanced Science, EarlyView.KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao +25 more
wiley +1 more source