Results 251 to 260 of about 693,481 (331)

AI-driven discovery of antiretroviral drug bictegravir and etravirine as inhibitors against monkeypox and related poxviruses. [PDF]

Commun Biol
Wang Y, Ünlü A, Wang X, Çevrim E, Offermans DM, Flesseman MP, Zaeck LM, Wu L, Bijvelds MJC, Sam-Agudu NA, de Vries RD, Raymond K, Li P, Olğaç A, Wang W, Doğan T, Pan Q.   +16 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Genome-wide strand-specific UV mutagenesis in <i><i>Escherichia coli</i></i> is directed by the Mfd translocase. [PDF]

Proc Natl Acad Sci U S A
Adebali O, Mieczkowski PA, Sancar A, Selby CP.   +3 more
europepmc   +1 more source

A Protein Complex Required for Polymerase V Transcripts and RNA- Directed DNA Methylation in Arabidopsis

Current Biology, 2010
Julie A. Law, Israel Ausín, L. Johnson, A. Vashisht, Jian‐Kang Zhu, J. Wohlschlegel, S. Jacobsen   +6 more
semanticscholar   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Identification and application of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase (HPPD) alleles via directed evolution. [PDF]

Plant Biotechnol J
Zhao B, Wang Y, Zhou M, Liu X, Li H, Shi Z, Guo Y, Li T, Yang F, Wang R, Zhao J, Liu Y.   +11 more
europepmc   +1 more source

Direct Detection of Epstein‐Barr Virus DNA from a Single Reed‐Sternberg Cell of Hodgkin's Disease by Polymerase Chain Reaction [PDF]

, 1992
Norihiro Teramoto, Tadaatsu Akagi, Tadashi Yoshino, Kiyoshi Takahashi, Ho Jong Jeon   +4 more
openalex   +1 more source

Dicer-independent RNA-directed DNA methylation in Arabidopsis

Cell Research, 2015
Dong-Lei Yang, Guiping Zhang, K. Tang, Jingwen Li, Lan Yang, Huan‐Wei Huang, Heng Zhang, Jian‐Kang Zhu   +7 more
semanticscholar   +1 more source

Generation of alphoid DNA probes for fluorescence in situ hybridization using the polymerase chain reaction [PDF]

, 1994
Cremer, Thomas, Dunham, Ian, Featherstone, Terry, Lengauer, Christoph   +3 more
core  

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source