Results 271 to 280 of about 662,270 (393)

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Strategic base modifications refine RNA function and reduce CRISPR-Cas9 off-targets. [PDF]

Nucleic Acids Res
Zhang K, Shen W, Zhao Y, Xu X, Liu X, Qi Q, Huang S, Tian T, Zhou X.   +8 more
europepmc   +1 more source

Functional implications of C-terminus of TBX5 with high homology to C-terminal domain of yeast DNA-directed RNA polymerase II largest subunit

, 2008
Zhuren Zhou, Li-Guo Gong, Wenqing Geng, Qiu Guang-rong, Kailai Sun   +4 more
openalex   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

The Genetic Determinants of Extreme UV Radiation and Desiccation Tolerance in a Bacterium Recovered from the Stratosphere. [PDF]

Microorganisms
Ellington AJ, Schult TJ, Reisch CR, Christner BC.   +3 more
europepmc   +1 more source

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses II. Directing Influence of RNA in the Reaction [PDF]

, 1972
Jonathan Leis, Jerard Hurwitz
openalex   +1 more source

Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer

Advanced Science, EarlyView.
Coatomer protein complex subunit α facilitates the transport of the cargo protein LRPPRC across the Golgi complex and enhances its stability, thereby increasing LRPPRC expression; LRPPRC promotes the stability of ID3 mRNA in an m6A‐dependent manner, thereby decreasing the transcriptional activity of p16 and p21, which leads to increased erdafitinib ...
Huayuan Zhao, Xincheng Gao, Yangkai Jiang, Yanchao Yu, Liang Wang, Jiayin Sun, Miao Wang, Xing Xiong, Chao Huang, Hui Zhang, Guosong Jiang   +10 more
wiley   +1 more source

Measuring XNA polymerase fidelity in a hydrogel particle format. [PDF]

Nucleic Acids Res
Medina EL, Chaput JC.
europepmc   +1 more source

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses I. Directing Influence of DNA in the Reaction [PDF]

, 1972
Jerard Hurwitz, Jonathan Leis
openalex   +1 more source