Results 91 to 100 of about 48,433 (280)

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. [PDF]

, 2017
DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Chen, Xuemei, Feng, Ying, Gao, Lei, Guo, Hongwei, Kim, Yun Ju, Law, Julie A, Le, Brandon, Li, Dongming, Li, Shaofang, Li, Shengben, Liu, Jinyuan, Liu, Li, Liu, Xigang, Mo, Beixin, Palanca, Ana Marie S, Vashisht, Ajay A, Wohlschlegel, James A, Won, So Youn, Wu, Xiuyun, Yang, Guodong, Zhao, Yuanyuan   +20 more
core   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]

, 2011
According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan, Israr Khan, Muhammad Waheed Akktar   +2 more
core   +1 more source

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair [PDF]

, 2013
Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
A Vaisman, AL Lu, Alexandra Vaisman, AR Fernández de Henestrosa, B Hiller, B Rydberg, B Van Houten, BD Davis, Bennett Van Houten, D Mu, DJ Crowley, DL Croteau, DL Croteau, DM Maron, Donald Huston, E Curti, E Wolff, EA Kouzminova, EF DeRose, EG Frank, EG Frank, EW Hou, F Lazzaro, G Churchward, G Jiang, GF Moolenaar, H Krokan, H Ohmori, H Shinagawa, H Wang, IJ Fijalkowska, J Yang, JA Brown, JB Sweasy, JC Huang, JE Sale, JG Moggs, JJ Lin, JJ Truglio, JL Sparks, John P. McDonald, JP McDonald, K Sugasawa, L Garibyan, L Zheng, LA Christensen, Lili Liu, M Sandigursky, M Skorvaga, M Tang, M Watanabe-Akanuma, M Yamaguchi, MA Reijns, MC Wahl, ME Branum, MM Ghodgaonkar, MR Albertella, N Kim, Q Jiang, Q Ruan, R Cone, R Woodgate, RJ Sanderson, Roger Woodgate, RP Cunningham, SA Lujan, SA Nick McElhinny, SA Nick McElhinny, Sue Jinks-Robertson, T Baba, T Lindahl, T Lindahl, T Nakano, W Kuban, W Yang, Wojciech Kuban, Y Shen, YW Kow   +77 more
core   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence

Journal of Translational Medicine
Background The primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their potential for early detection of lymph node metastasis.
Khalil Khashei Varnamkhasti, Mehdi Moghanibashi, Sirous Naeimi   +2 more
doaj   +1 more source

Subunit Compositions of Arabidopsis DNA-Dependent RNA Polymerases and the Roles of the Plant-Specific RNA Polymerases IV and V in Gene Silencing [PDF]

, 2009
In addition to RNA polymerases I, II and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, abbreviated as Pol IV and Pol V, that play non-redundant roles in siRNA-directed DNA methylation ...
Ream, Thomas
core   +1 more source

The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III [PDF]

, 1997
In both yeast and mammalian systems, considerable progress has been made toward the characterization of the transcription factors required for transcription by RNA polymerase III. However, whereas in yeast all of the RNA polymerase III subunits have been
Hernandez, N., Sepehri, S.
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A Chemical Kinetic Model of Transcriptional Elongation [PDF]

arXiv, 2006
A chemical kinetic model of the elongation dynamics of RNA polymerase along a DNA sequence is introduced. The proposed model governs the discrete movement of the RNA polymerase along a DNA template, with no consideration given to elastic effects. The model's novel concept is a ``look-ahead'' feature, in which nucleotides bind reversibly to the DNA ...
arxiv