Results 211 to 220 of about 26,138 (240)

Structural basis of error-prone DNA synthesis by DNA polymerase θ. [PDF]

Nat Commun
Li C, Maksoud LM, Gao Y.
europepmc   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Harnessing microbial heterogeneity for improved biosynthesis fueled by synthetic biology. [PDF]

Synth Syst Biotechnol
Cao Y, Li J, Liu L, Du G, Liu Y.
europepmc   +1 more source

An evolved, orthogonal ssDNA generator for targeted hypermutation of multiple genomic loci. [PDF]

Nucleic Acids Res
Chu W, Tian R, Guo Y, Wu Y, Rehm FBH, Liu L, Li J, Du G, Chen J, Liu Y.   +9 more
europepmc   +1 more source

Structural dynamic investigation of the mutation-induced resistance mechanisms of Mycobacterium tuberculosis DNA-directed RNA polymerase against Rifampicin

Mokgerwa Zacharia Monama
openalex   +1 more source

A Protein Complex Required for Polymerase V Transcripts and RNA- Directed DNA Methylation in Arabidopsis

, 2010
Julie A. Law, Israel Ausín, Lianna M. Johnson, Ajay A. Vashisht, Jian‐Kang Zhu, James A. Wohlschlegel, Steven E. Jacobsen   +6 more
openalex   +1 more source

Integrating PLOR and SPAAC Click Chemistry for Efficient Site-Specific Fluorescent Labeling of RNA. [PDF]

Int J Mol Sci
Xue Y, Si X, Yin D, Zhang S, Dai H.
europepmc   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source

Mathematical model of RNA-directed DNA methylation predicts tuning of negative feedback required for stable maintenance. [PDF]

Open Biol
Dale R, Mosher R.
europepmc   +1 more source

Antiviral effects and mechanism of Qi pi pill against influenza viruses

Animal Models and Experimental Medicine, EarlyView.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang, Jing Gao, Meiyue Dong, Carolina Q. Sacramento, Ping Li, Xiangyu Lian, Lingyuan Fan, Lijun Rong, Ruikun Du, Jingzhen Tian, Qinghua Cui   +10 more
wiley   +1 more source