Results 51 to 60 of about 1,587,193 (206)

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Annotation data for 13-C enriched MAGs from DNA SIP with anaerobic butyrate degrading microcosms

, 2019
These files include Genbank formatted annotation information on the two 13C-enriched MAGs from DNA-SIP experiments with 13-C labelled ...
Ryan Ziels (6391640)
core   +1 more source

Nanopore sequencing enables novel detection of deuterium incorporation in DNA

Computational and Structural Biotechnology Journal
Identifying active microbes is crucial to understand their role in ecosystem functions. Metabolic labeling with heavy, non-radioactive isotopes, i.e., stable isotope probing (SIP), can track active microbes by detecting heavy isotope incorporation in ...
Christian Höner zu Siederdissen, Jannes Spangenberg, Kevin Bisdorf, Sebastian Krautwurst, Akash Srivastava, Manja Marz, Martin Taubert   +6 more
doaj   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Estabelecimento de sessões SIP com garantias de Qos e sua aplicação em domínios DiffServ [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência da Computação, Florianópolis, 2010A maior parte das soluções de gerenciamento de Qualidade de Serviço (QoS) realizam o tratamento ...
Vicente, Luiz Henrique
core  

Genome fasta files for 13-C enriched genomes from DNA-SIP with anaerobic butyrate degrading microcosms

, 2019
These files include genome sequences in FASTA format for the two 13-C enriched MAGs from DNA-SIP with labelled butyrate in anaerobic ...
Ryan Ziels (6391640)
core   +1 more source

Cultivation and characterization of functional-yet-uncultivable phenanthrene degraders by stable-isotope-probing and metagenomic-binning directed cultivation (SIP-MDC)

Environment International
High-throughput identification and cultivation of functional-yet-uncultivable microorganisms is a fundamental goal in environmental microbiology. It remains as a critical challenge due to the lack of routine and effective approaches.
Jibing Li, Chunling Luo, Xixi Cai, Yeliang Dai, Dayi Zhang, Gan Zhang   +5 more
doaj   +1 more source

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Data_Sheet_1_13C-DNA-SIP Distinguishes the Prokaryotic Community That Metabolizes Soybean Residues Produced Under Different CO2 Concentrations.pdf

, 2019
The amendment of crop residues produced under elevated CO2 (eCO2) may alter soil microbial community structure and their functions on residue decomposition and carbon (C) cycling in soil.
Zhihuang Xie (7420487), Xiaobing Liu (522170), Caixian Tang (715958), Yansheng Li (3328095), Junjie Liu (193511), Zhenhua Yu (522169), Yanhong Wang (305822), Guanghua Wang (522171), Jian Jin (351142)   +8 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source