Results 91 to 100 of about 4,247,719 (263)

Nanopore sequencing enables novel detection of deuterium incorporation in DNA

Computational and Structural Biotechnology Journal
Identifying active microbes is crucial to understand their role in ecosystem functions. Metabolic labeling with heavy, non-radioactive isotopes, i.e., stable isotope probing (SIP), can track active microbes by detecting heavy isotope incorporation in ...
Christian Höner zu Siederdissen, Jannes Spangenberg, Kevin Bisdorf, Sebastian Krautwurst, Akash Srivastava, Manja Marz, Martin Taubert   +6 more
doaj   +1 more source

Linking Specific Heterotrophic Bacterial Populations to Bioreduction of Uranium and Nitrate in Contaminated Subsurface Sediments by Using Stable Isotope Probing

, 2011
Shifts in terminal electron-accepting processes during biostimulation of uranium-contaminated sediments were linked to the composition of stimulated microbial populations using DNA-based stable isotope probing. Nitrate reduction preceded U(VI) and Fe(III)
Lee Kerkhof, Joel E. Kostka, Anthony V. Palumbo, Denise M. Akob, Kirsten Küsel, David B. Watson   +5 more
core   +1 more source

MicroCT reinvestigation of the only articulated fossil anostomid fish reveals synonymy of Arhinolemur Ameghino, 1898 and Megaleporinus Ramirez et al., 2017

The Anatomical Record, EarlyView.
Abstract Arhinolemur scalabrinii† Ameghino, 1898 was originally described as a strepsirrhine primate (Mammalia) but has been recognized as an anostomid fish since 2012. It remains the only extinct anostomid species known from complete cranial material.
Karen M. Panzeri, Humberto L. Andrelino, Sergio Bogan, José P. O'Gorman, Federico Agnolín, Brian L. Sidlauskas, Nahuel Vega, Agustín G. Martinelli, José L. Birindelli   +8 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

SIPSim: A Modeling Toolkit to Predict Accuracy and Aid Design of DNA-SIP Experiments

Frontiers in Microbiology, 2018
DNA Stable isotope probing (DNA-SIP) is a powerful method that links identity to function within microbial communities. The combination of DNA-SIP with multiplexed high throughput DNA sequencing enables simultaneous mapping of in situ assimilation ...
Nicholas D. Youngblut, Samuel E. Barnett, Daniel H. Buckley   +2 more
doaj   +1 more source

A review of the inhibitory waste metabolites produced during mAb biomanufacturing

Biotechnology Progress, EarlyView.
The review highlights inhibitory metabolites in CHO cell cultures, such as lactate, ammonia, isobutyrate, and isovalerate, impacting growth and productivity. Identification methods include LC/MS‐based metabolomics, while control strategies involve media optimization, genetic engineering, and process adjustments (pH, temperature).
Zhao Wang, Caitlin Morris, Duc Hoang, Jianlin Xu, Michael C. Borys, Seongkyu Yoon   +5 more
wiley   +1 more source

Direct Utilization of Organic Nitrogen by Phytoplankton and Its Role in Nitrogen Cycling Within the Southern California Bight

Frontiers in Microbiology, 2018
The new production model attempts to quantify the amount of organic material exported from surface waters based on the form of nitrogen (N) being utilized.
Michael Morando, Douglas G. Capone
doaj   +1 more source

Stable isotope probing of hydrocarbon-degraders.

, 2010
Microbes govern a plethora of biogeochemical reactions in natural systems. Especially, they are crucial for the degradation of hydrocarbons and contaminants under both aerobic and anaerobic conditions. Only in the last 1–2 decades, researchers have
T. Lueders, Lüders, T.
core   +1 more source

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, Volume 32, Issue 42, 12 November 2026.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

Stable-Isotope Probing RNA to Study Plant/Fungus Interactions

, 2016
International audienceThe use of stable-isotope probing (SIP) allows tracing specific labeled substrates into fungi leading to a better understanding of their role in biogeochemical cycles and their relationship with their environment.
Amandine Lê Van, Vandenkoornhuyse, Philippe, Duhamel, Marie, Philippe Vandenkoornhuyse, Lê Van, Amandine, Quaiser, Achim, Achim Quaiser, Marie Duhamel   +7 more
core   +1 more source