Results 171 to 180 of about 7,795,985 (403)

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, 2018
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target.
Sairy Hernandez, Jing Qing, Rebecca Hong Thibodeau, Xiangnan Du, Summer Park, Hyang-Mi Lee, Min Xu, Soyoung Oh, Armando Navarro, Meron Roose-Girma, Robert J. Newman, Soren Warming, Michelle Nannini, Deepak Sampath, Jeong M. Kim, Jane L. Grogan, Ira Mellman   +16 more
doaj  

DNA Barcoding studies on Thrips in India: Cryptic species and Species complexes

Scientific Reports, 2017
Thrips are one of the major sucking pest and vector of plant viruses causing huge economic loss in agriculture. The accurate identification of thrips is crucial for effective pest management strategies.
Kaomud Tyagi, Vikas Kumar, Devkant Singha, Kailash Chandra, Boni Amin Laskar, Shantanu Kundu, Rajasree Chakraborty, Sumantika Chatterjee   +7 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Molecular Dynamics Simulations of a Nucleosome and Free DNA [PDF]

arXiv, 2004
Nucleosomes organize the folding of DNA into chromatin and significantly influence transcription, replication, regulation and repair. All atom molecular dynamics simulations of a nucleosome and of its 146 basepairs of DNA free in solution have been conducted.
arxiv  

A DEVELOPMENTAL ANALYSIS OF THE LETHAL MUTANT L(2)GL OF DROSOPHILA MELANOGASTER BASED ON CYTOPHOTOMETRIC DETERMINATION OF NUCLEAR DESOXYRIBONUCLEIC ACID (DNA) CONTENT [PDF]

, 1957
R. M. Welch
openalex   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Estudio y validación de los microsatélites D1S1656, D12S391 y D18S535 en las poblaciones de Antioquia y Chocó

Acta Biológica Colombiana, 2001
En este trabajo se describen las frecuencias alélicas, la distribución fenotípica y los parámetrosestadísticos de interés forense de los loci STRs D1S1656, D12S391 y D18S535, en las pobla-ciones colombianas de Antioquia y Chocó.La tipificación se realizó
JJ. Builes, C. Salazar, M. Martínez-Pancorbo, MA. Moreno, CP. Gómez, ML. Bravo   +5 more
doaj  

THE EXTENT OF THE ENZYMATIC DEGRADATION OF DESOXYRIBONUCLEIC ACID (DNA) IN PURULENT EXUDATES BY STREPTODORNASE 123 [PDF]

, 1950
Sol Sherry, John P. Goeller
openalex   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source