Results 61 to 70 of about 7,795,985 (403)
Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion [PDF]
, 2005 Type IB DNA topoisomerases cleave and rejoin one strand of the DNA duplex, allowing for the removal of supercoils generated during replication and transcription.
Dekker, Cees +5 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2019 Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface.
Changchun Du +8 more
doaj +1 more source
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines
Nature Communications, 2021 The utility of AsCas12a can be limited to poor editing efficiency. Here the authors identify a variant, “AsCas12a Ultra”, that has high on-target specificity demonstrated through editing of clinically relevant T cell genes.
Liyang Zhang +23 more
doaj +1 more source
DMSO Improves the Ski-Slope Effect in Direct PCR
Applied Sciences, 2021 Analytical techniques such as DNA profiling are widely used in various fields, including forensic science, and novel technologies such as direct polymerase chain reaction (PCR) amplification are continuously being developed in order to acquire DNA ...
Joo-Young Kim +6 more
doaj +1 more source
DnaSP, DNA polymorphism analyses by the coalescent and other methods
Bioinform., 2003 SUMMARY DnaSP is a software package for the analysis of DNA polymorphism data. Present version introduces several new modules and features which, among other options allow: (1) handling big data sets (approximately 5 Mb per sequence); (2) conducting a ...
J. Rozas +3 more
semanticscholar +1 more source
DNA-coated Functional Oil Droplets
, 2017 Many industrial soft materials often include oil-in-water (O/W) emulsions at the core of their formulations. By using tuneable interface stabilizing agents, such emulsions can self-assemble into complex structures.
Bruns, Nico +8 more
core +2 more sources
Polymer induced condensation of dna supercoils [PDF]
, 2008 Macromolecular crowding is thought to be a significant factor driving DNA condensation in prokaryotic cells. Whereas DNA in prokaryotes is supercoiled, studies on crowding-induced DNA condensation have so far focused on linear DNA.
Bessa Ramos Jr., J.E. +2 more
core +2 more sources
Population Ecology, EarlyView.In the process of captive breeding and reintroduction of endangered animal species, it is crucial to minimize familial bias in reproductive success during the reintroduction phase to preserve genetic diversity. In this study, we attempted to identify the familial lineage of individuals of the endangered bagrid fish Tachysurus ichikawai born at the ...
Hinano Mizuno +5 more
wiley +1 more source
Nature Communications, 2019 Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
Yu Kong +14 more
doaj +1 more source