Results 141 to 150 of about 2,473,744 (242)

Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer. [PDF]

J Pers Med
Gajewski F, Pec J, Kleinrok J, Pająk W, Pacyna K, Tokarzewska A, Krawczyk P.   +6 more
europepmc   +1 more source

Positive feedback drives a secondary nonlinear product burst during a biphasic DNA amplification reaction. [PDF]

Analyst, 2022
Özay B, Murphy SD, Stopps EE, Gedeon T, McCalla SE.   +4 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Topoisomerase III limits RecA-dependent DNA amplification in the chromosome terminus with RecG. [PDF]

Nucleic Acids Res
Dadras A, Le Campion A, Drolet M.
europepmc   +1 more source

Improved visual detection of DNA amplification using pyridylazophenol metal sensing dyes. [PDF]

Commun Biol, 2022
Zhang Y, Hunt EA, Tamanaha E, Corrêa IR, Tanner NA.   +4 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

RAF1 extrachromosomal DNA amplification confers acquired erlotinib resistance in a non-small cell lung cancer cell model. [PDF]

Signal Transduct Target Ther
Kim S, Kim B, Lim A, Kim H, Cho J.
europepmc   +1 more source

Closed-Loop Microreactor on PCB for Ultra-Fast DNA Amplification: Design and Thermal Validation. [PDF]

Micromachines (Basel), 2023
Skaltsounis P, Kokkoris G, Papaioannou TG, Tserepi A.   +3 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A breakage-replication/fusion process explains complex rearrangements and segmental DNA amplification. [PDF]

Nat Genet
Zhang CZ, Mendez-Dorantes C, Burns KH, Pellman D.   +3 more
europepmc   +1 more source