Results 191 to 200 of about 108,337 (292)

A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus

Arthritis &Rheumatology, EarlyView.
Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity, and incidence of SLE.
Nancy J. Olsen, Duanping Liao, Judith A. James, Joel M. Guthridge, Cristina Arriens, Diane Kamen, Mariko Ishimori, Daniel J. Wallace, Christopher Striebich, Sonali Narain, Benjamin F. Chong, Fan He, Eric W. Schaefer, Vernon M. Chinchilli, David R. Karp   +14 more
wiley   +1 more source

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Correction to "Advancing Yeast Identification Using High-Throughput DNA Barcode Data From a Curated Culture Collection". [PDF]

Mol Ecol Resour
europepmc   +1 more source

Long‐term trends in parasite diversity and infection levels: approaches and patterns

Biological Reviews, EarlyView.
ABSTRACT Parasites exist in every ecosystem, affecting nearly all organisms and playing a complex role in human societies. On the one hand, they contribute substantially to biodiversity and support ecosystem stability by performing essential ecological functions.
Cyril Hammoud, Juan Antonio Balbuena, Isabel Blasco‐Costa, Katie O'Dwyer, Rachel A. Paterson, Tomáš Scholz, Christian Selbach, Bernd Sures, David W. Thieltges   +8 more
wiley   +1 more source

Australia's marine fishes DNA barcode reference library for integrated taxonomy, metabarcoding & eDNA research. [PDF]

Sci Data
Appleyard SA, Ward RD, Pogonoski JJ, Graham A, Last PR, Deagle BE, Holmes B, Gomon MF, Bray DJ, Johnson JW, Hay AC, Moore GI, Hammer MP, Russell B, Graham KJ.   +14 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Cryptic Diversity and Climatic Niche Divergence of <i>Brillia</i> Kieffer (Diptera: Chironomidae): Insights from a Global DNA Barcode Dataset. [PDF]

Insects
Xu HF, Lv MY, Zhao Y, Zhang ZC, Liu Z, Lin XL.   +5 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Exploratory Study on DNA Barcode Combined with PCR-HRM Technology for Rapid and Accurate Identification of Necrophilous Fly Species. [PDF]

Insects
Wang B, Ha S, Cai J, Ma Y, Li D, Chen J, Deng J.   +6 more
europepmc   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source