Results 1 to 10 of about 113,396 (329)

DNA Sliding Clamps: Just the Right Twist to Load onto DNA [PDF]

Current Biology, 2005
Two recent papers illuminate a key step in DNA sliding clamp loading: one reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while the other finds that the clamp may assist this process by forming a right-handed helix upon opening.
Daniel Barsky, Česlovas Venclovas
openalex   +3 more sources

The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis. [PDF]

J Biol Chem, 2022
Manohar K, Khandagale P, Patel SK, Sahu JK, Acharya N.   +4 more
europepmc   +1 more source

Naked-Eye Molecular Testing for the Detection of Xylella fastidiosa in Mallorca (Balearic Island) Almond Orchards by Colorimetric LAMP

Applied Sciences
Xylella fastidiosa (Xf) is a quarantine pathogen heavily affecting economically important crops worldwide. Different sequence types (STs) belonging to Xf subspecies are present in various areas of Spain, including the Balearic Islands, and cause the ...
Amoia Serafina Serena, Ana Falcón-Piñeiro, Milica Pastar, José Manuel Garcìa-Madero, Nicoletta Contaldo, Mikael Muegge, Stéphane Compant, Pasquale Saldarelli, Angelantonio Minafra   +8 more
doaj   +1 more source

Structural insights into the function of ZRANB3 in replication stress response

Nature Communications, 2017
ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks.
Marek Sebesta, Christopher D. O. Cooper, Antonio Ariza, Christopher J. Carnie, Dragana Ahel   +4 more
doaj   +1 more source

The repetitive structure of DNA clamps: An overlooked protein tandem repeat

, 2023
Paula Nazarena Arrías, Alexander Miguel Monzón, Damiano Clementel, Soroush Mozaffari, Damiano Piovesan, Andrey V. Kajava, Silvio C. E. Tosatto   +6 more
openalex   +2 more sources

Characterization of the Escherichia coli XPD/Rad3 iron-sulfur helicase YoaA in complex with the DNA polymerase III clamp loader subunit chi (χ) [PDF]

, 2022
Savannah J. Weeks-Pollenz, Yasmin Ali, Leslie A. Morris, Vincent A. Sutera, Elizabeth E. Dudenhausen, Margaret Hibnick, Susan T. Lovett, Linda B. Bloom   +7 more
openalex   +1 more source

Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome

The EMBO Journal
During DNA replication, the DNA polymerases Pol δ and Pol ε utilise the ring-shaped sliding clamp PCNA to enhance their processivity. PCNA loading onto DNA is accomplished by the clamp loaders RFC and Ctf18-RFC, which function primarily on the lagging ...
Emma E Fletcher, Morgan L Jones, Joseph T P Yeeles   +2 more
doaj   +1 more source

Structure-Function Analysis of the S. Cerevisiae PCNA Clamp-An Essential Protein in DNA Metabolism [PDF]

, 2011
Yayan Zhou, Manju Hingorani
openalex   +1 more source

Multiple C-Terminal Tails within a Single \u3cem\u3eE. coli\u3c/em\u3e SSB Homotetramer Coordinate DNA Replication and Repair [PDF]

, 2013
Escherichia coli single-stranded DNA binding protein (SSB) plays essential roles in DNA replication, recombination and repair. SSB functions as a homotetramer with each subunit possessing a DNA binding domain (OB-fold) and an intrinsically disordered C ...
Antony, Edwin, Kozlov, Alexander G., Lohman, Timothy M., Manhart, Carol M., McHenry, Charles S., Nguyen, Binh, Weiland, Elizabeth, Yuan, Quan   +7 more
core   +1 more source

Position of Premature Termination Codons Determines Susceptibility of hERG Mutations to Nonsense-Mediated mRNA Decay in Long QT Syndrome

, 2014
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +1 more source