Results 101 to 110 of about 113,396 (329)

Intrinsic stability and oligomerization dynamics of DNA processivity clamps [PDF]

Nucleic Acids Research, 2014
Sliding clamps are ring-shaped oligomeric proteins that are essential for processive deoxyribonucleic acid replication. Although crystallographic structures of several clamps have been determined, much less is known about clamp structure and dynamics in solution.
Binder, Jennifer K., Douma, Lauren G., Ranjit, Suman, Kanno, David M., Chakraborty, Manas, Bloom, Linda B., Levitus, Marcia   +6 more
openaire   +3 more sources

Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications

Advanced Materials, EarlyView.
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa, Paolo Blesio, Marcial Fernandez‐Castro, Lisa Almonte, Maxence Fernandez, Mantas Liutkus, Perumal Pandurangan, Carlos Sabater, Aitor Villaverde, Manuel Melle‐Franco, Nurit Ashkenasy, Felipe Jiménez‐Ángeles, M. Carmen Morant‐Miñana, M. Reyes Calvo, Aitziber L. Cortajarena   +14 more
wiley   +1 more source

Clamping down on mismatches

eLife, 2016
A sliding clamp complex may help correct DNA replication errors by keeping track of which DNA strand is new and which is the template.
Guo-Min Li
doaj   +1 more source

Self‐Assembled Inorganic Nanomembrane Tubes: Rolled‐Up Piezoelectrics for Microacoustic Wave‐Based Actuators and Sensors

Advanced Materials, EarlyView.
This study demonstrates a self‐assembly process to generate free‐standing piezoelectric nanomembranes, forming ultracompact microtubular acoustic wave sensors and actuators. The miniaturized 3D piezoelectric platform reported in this work can be applied in telecommunication, energy harvesting, and acoustofluidics. Moreover, the 3D self‐assembly can add
Raphaël C. L‐M. Doineau, Christian N. Saggau, Stefan Baunack, Thomas Gemming, Yara Abdelaal, Robert Weser, Oliver G. Schmidt, Hagen Schmidt, Andreas Winkler, Mariana Medina‐Sánchez   +9 more
wiley   +1 more source

Stretching of proteins in a uniform flow

, 2006
Stretching of a protein by a fluid flow is compared to that in a force-clamp apparatus. The comparison is made within a simple topology-based dynamical model of a protein in which the effects of the flow are implemented using Langevin dynamics.
Chan E. Y., Marek Cieplak, P. Szymczak
core   +1 more source

The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time [PDF]

, 2006
Peer ...
Andrulis ED, Anne D Donaldson, Askree SH, Bermudez VP, Boulton SJ, Bowman GD, Bylund GO, Bystricky K, Cosgrove AJ, Dimitrova DS, Donaldson AD, E Douglas Robertson, Ferguson BM, Gartenberg MR, Gilbert DM, Gilbert N, Gotta M, Gottschling DE, Gravel S, Hanna JS, Hayashi A, Hediger F, Heun P, Heun P, Kenna MA, Kim J, Laroche T, Martin SG, Mayer ML, Merkle CJ, Naiki T, Ohta S, Palladino F, Petronczki M, Porter SE, Raghuraman MK, Raghuraman MK, Roy R, Shin-ichiro Hiraga, Skibbens RV, Smolikov S, Stellwagen AE, Stevenson JB, Strahl-Bolsinger S, Straight AF, Suter B, Taddei A, Taddei A, Tanabe H, Tanaka T, Tham WH, Woodfine K   +51 more
core   +2 more sources

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Critical Function of γH2A in S-Phase. [PDF]

PLoS Genetics, 2015
Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clastogens,
Eva Mejia-Ramirez, Oliver Limbo, Petra Langerak, Paul Russell   +3 more
doaj   +1 more source

Multiple prebiotic metals mediate translation. [PDF]

, 2018
Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a ...
Bowman, Jessica C, Bray, Marcus S, Glass, Jennifer B, Haynes, Jay William, Hud, Nicholas V, Lenz, Timothy K, Petrov, Anton S, Reddi, Amit R, Williams, Loren Dean   +8 more
core   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source