Results 281 to 290 of about 113,396 (329)

Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria. [PDF]

Int J Mol Sci
Maj P, Trylska J.
europepmc   +1 more source

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

3D-MINFLUX nanoscopy reveals distinct allosteric mechanisms for activation and modulation of PIEZO1 by Yoda1. [PDF]

Nat Commun
Verkest C, Roettger L, Zeitzschel N, Lechner SG.   +3 more
europepmc   +1 more source

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

Glia, Volume 74, Issue 2, February 2026.
Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek, Krzysztof Goryca, Dorota Adamska, Joanna Urban‐Ciećko, Katarzyna Hryniewiecka, Marcin Lipiec, Tomasz Grzegorz Krawczyk, Kamil Rafalko, Alicja Ławicka, Shane A. Liddelow, Lukasz Mateusz Szewczyk   +10 more
wiley   +1 more source

Bipolar, not tetrapolar: mating system determination in Inonotus hispidus through genomic and phenotypic analysis. [PDF]

Appl Microbiol Biotechnol
Chen Y, Li S, Zhang J, Jiang Y, Zhao M, Hou Z, Huang C.   +6 more
europepmc   +1 more source

Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC

Glia, Volume 74, Issue 2, February 2026.
Mechanical properties of Mlc1‐null astrocytes are altered. Cytoskeleton‐related pathways are dysregulated in Mlc1‐null astrocytes. Mlc1‐null astrocytes show alterations in focal adhesions, which link the cytoskeleton to the extracellular matrix. ABSTRACT Loss of function of the astrocyte protein MLC1 causes Megalencephalic Leukoencephalopathy with ...
Quinty Bisseling, Emma M. J. Passchier, Freya M. Kirwan, Nelda Antonovaite, Serena Camerini, Maria S. Brignone, Amélie Freal, Huibert D. Mansvelder, Elena Ambrosini, Marjo S. van der Knaap, Rogier Min   +10 more
wiley   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition. [PDF]

Nucleic Acids Res
Lee JH, Thomsen M, Daub H, Thieulin-Pardo G, Steinbacher S, Sztyler A, Dahiya V, Neudegger T, Dominguez C, Iyer RR, Wilkinson HA, Monteagudo E, Plotnikov NV, Felsenfeld DP, Haque TS, Finley M, Boudet J, Vogt TF, Prasad BC.   +18 more
europepmc   +1 more source

Molecular phylogeny and morphological characterization revealed Candolleomyces mianwaliensis Psathyrellaceae, Agaricales, a new species from Punjab, Pakistan

Nordic Journal of Botany, Volume 2026, Issue 2, February 2026.
Candolleomyces mianwaliensis is described as a new species from Mianwali District, Punjab Pakistan. The species is characterized by spherical to plane pileus bearing pale orange irregular scales scattered over smooth dark orange surface when young, turning into off‐white scales over brown to dark brown surface towards maturity, and a double membranous ...
Mehboobullah Khan, Memoona Azeem, Hira Ijaz, Wasiqa Arshad, Aasma Tufail, Sana Jabeen   +5 more
wiley   +1 more source

A dual-mechanism antimicrobial peptide with antimutagenic activity targets the replisome and induces cell envelope stress. [PDF]

mSphere
Singleton AH, Bergum OET, Scheffold J, Ræder SB, Thorfinnsdottir LB, Røst LM, Søgaard CK, Bruheim P, Otterlei M.   +8 more
europepmc   +1 more source