Results 91 to 100 of about 736,909 (260)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
تحسين خوارزمية MD5 بالاعتماد على عدة طرق
مجلة الغري للعلوم الاقتصادية والادارية, 2017 المستخلص خوارزميات Hash هي الجزء المهم في العديد من تطبيقات التشفير والبروتوكولات الأمنية . هذا البحث يعمل على تعزيز خوارزميةMD5 ضد بعض الهجمات. التطوير الذي تم اعتماده في تحسين خوارزمية MD5 هو استخدام DNA coding ، والمعادلات الغير خطية (NLFSR ...
علاء فرحان +1 more
doaj +1 more source
Research on Improved DNA Coding and Multidirectional Diffusion Image Encryption Algorithm. [PDF]
Entropy (Basel), 2023 Liu J, Chang H, Ran W, Wang E.
europepmc +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review
Journal of Animal Science and Technology, 2018 The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2–3% of the genomic DNA is transcribed to protein-coding mRNA.
Jasdeep Kaur Dhanoa +4 more
doaj +1 more source
An Image Encryption Algorithm Based on Improved Hilbert Curve Scrambling and Dynamic DNA Coding. [PDF]
Entropy (Basel), 2023 Geng S, Li J, Zhang X, Wang Y.
europepmc +1 more source
Random Coding Bounds for DNA codes based on Fibonacci ensembles of DNA sequences
2008 IEEE International Symposium on Information Theory, 2008 We consider DNA codes based on the concept of a weighted 2-stem similarity measure which reflects the ldquohybridization potentialrdquo of two DNA sequences. A random coding bound on the rate of DNA codes with respect to a thermodynamic motivated similarity measure is proved. Ensembles of DNA strands whose sequence composition is restricted in a manner
D'yachkov, A. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The evolutionary progression of cancers
Academia OncologyIt is now generally recognized that cancer is a somatic evolutionary process driven by stepwise selection for single genetic mutations or stable epigenetic changes, resulting from specific DNA methylations.
Walter F. Bodmer
doaj +1 more source