Results 91 to 100 of about 2,751,270 (241)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

DNA coding combinations.

open access: yes, 2018
DNA coding combinations.
Cheng Song (845259)   +2 more
core   +1 more source

Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review

open access: yesJournal of Animal Science and Technology, 2018
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2–3% of the genomic DNA is transcribed to protein-coding mRNA.
Jasdeep Kaur Dhanoa   +4 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Transcription influences repair-induced DNA methylation [PDF]

open access: yes, 2008
This work is aimed at the dissection of the molecular mechanism(s) linking DNA damage and gene silencing. To this end, we have developed a genetic system that allows a rapid assessment of homologous-directed repair (HR) of an unique DNA double strand ...
Morano, Annalisa
core   +1 more source

The evolutionary progression of cancers

open access: yesAcademia Oncology
It is now generally recognized that cancer is a somatic evolutionary process driven by stepwise selection for single genetic mutations or stable epigenetic changes, resulting from specific DNA methylations.
Walter F. Bodmer
doaj   +1 more source

تحسين خوارزمية MD5 بالاعتماد على عدة طرق

open access: yesمجلة الغري للعلوم الاقتصادية والادارية, 2017
المستخلص خوارزميات Hash  هي الجزء المهم في العديد من تطبيقات التشفير والبروتوكولات الأمنية .  هذا البحث يعمل على تعزيز خوارزميةMD5  ضد بعض الهجمات. التطوير الذي تم اعتماده في تحسين خوارزمية MD5  هو  استخدام DNA coding ، والمعادلات الغير خطية (NLFSR ...
علاء فرحان   +1 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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