Results 101 to 110 of about 2,751,270 (241)

Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.

PLoS Genetics, 2011
There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood.
Christine M Williamson, Simon T Ball, Claire Dawson, Stuti Mehta, Colin V Beechey, Martin Fray, Lydia Teboul, T Neil Dear, Gavin Kelsey, Jo Peters   +9 more
doaj   +1 more source

Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene. [PDF]

PLoS One, 2023
Fernandez TV, Williams ZP, Kline T, Rajendran S, Augustine F, Wright N, Sullivan CAW, Olfson E, Abdallah SB, Liu W, Hoffman EJ, Gupta AR, Singer HS.   +12 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

DNA Coding using Finite-Context Models and Arithmetic Coding

, 2009
The interest in DNA coding has been growing with the avail-ability of extensive genomic databases. Although only two bits are sufficient to encode the four DNA bases, efficient lossless compression methods are still needed due to the size of DNA ...
O J. Pinho, Armando J. Pinho, Paulo J. S. G. Ferreira, Carlos A. C. Bastos, António J. R. Neves   +4 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Space-variant picture coding [PDF]

, 2010
PhDSpace-variant picture coding techniques exploit the strong spatial non-uniformity of the human visual system in order to increase coding efficiency in terms of perceived quality per bit.
Popkin, Timothy John
core   +2 more sources

Evolution analysis of FRIZZY PANICLE (FZP) orthologs explored the mutations in DNA coding sequences in the grass family (Poaceae). [PDF]

PeerJ, 2022
Li J, Zhang L, G Elbaiomy R, Chen L, Wang Z, Jiao J, Zhu J, Zhou W, Chen B, Soaud SA, Abbas M, Lin N, El-Sappah AH.   +12 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Role of Non-Coding Regions in Breast Cancer: From Gene Regulation to Therapeutic Implications

Pharmaceuticals
Breast cancer (BC) remains one of the most prevalent cancers worldwide and a significant cause of cancer-related mortality among women. Despite significant advancements in understanding the genetic foundations of BC, numerous research initiatives have ...
Hussein Sabit, Sara Sobhy, Shaimaa Abdel-Ghany, Al-Hassan Soliman Wadan, Olubukola Ayodele, Yasser Albrahim, Hirendra N. Banerjee, Ahmed Elhashash, Borros Arneth   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source