Results 81 to 90 of about 2,863,112 (293)
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses. [PDF]
PLoS ONE, 2009 BACKGROUND:The lack of correlation between genome size and organismal complexity is understood in terms of the massive presence of repetitive and non-coding DNA. This non-coding subgenome has long been called "junk" DNA.
Reiner A Veitia, Samuel Bottani
doaj +1 more source
Coding Over Sets for DNA Storage [PDF]
IEEE Transactions on Information Theory, 2018 20 ...
Andreas Lenz 0001 +3 more
openaire +5 more sources
Genome-wide analysis of coding DNA and amino acid variation in Saccharomyces cerevisiae
, 2008 The possible causes of variation on amino acid composition in the yeast Saccharomyces cerevisiae were investigated genome-wide. The results indicated that: (a) the base composition of coding DNA and amino acid composition was similar among all the ...
Wang, Jinxia +4 more
core +1 more source
Evidence for widespread degradation of gene control regions in hominid genomes. [PDF]
, 2005 Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these sequences are subject to some selective constraints ...
Peter D Keightley +11 more
core +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The role of highly conserved non-coding DNA sequences in vertebrate development and evolution [PDF]
, 2010 PhDComparisons between vertebrate genome sequences, from mammals to fishes, have revealed thousands of conserved non-coding elements (CNEs) that are associated with developmental genes.
Parker, Hugo
core +2 more sources
CRANN: detecting adaptive evolution in protein-coding DNA sequences
, 2003 A software program CRANN has been developed in order to detect adaptive evolution in protein-coding DNA ...
Mcinerney, James +2 more
core +6 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks [PDF]
International Journal of Molecular and Cellular Medicine, 2017 DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death.
Ali Dianatpour, Soudeh Ghafouri-Fard
doaj