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Yeasts have a four‐fold variation in ribosomal DNA copy number
Yeast, 1993AbstractBy employing pulsed‐field gel electrophoresis we have determined the size of the rDNA cluster in wild‐type yeast strains representing genera of Candida, Kluyveromyces, Pachysolen, Schizosaccharomyces and Torulaspora. Although the genome size of the examined species is similar (12·3–13·9 Mb), at least a four‐fold variation has been observed ...
R, Maleszka, G D, Clark-Walker
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Copy Number Variation Analysis on Cell-Free Serum DNA
2018Genome diversity comprises single nucleotide polymorphisms, deletions, insertions, and duplications. These gains and losses of DNA segments leading to rearrangements of sequences are termed copy number variations (CNVs). CNVs may disrupt genes and/or alter gene dosage and, thereby, have an impact on both protein-coding and noncoding genes. Accordingly,
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Transfer Learning across Cancers on DNA Copy Number Variation Analysis
2013 IEEE 13th International Conference on Data Mining, 2013DNA copy number variations (CNVs) are prevalent in all types of tumors. It is still a challenge to study how CNVs play a role in driving tumorgenic mechanisms that are either universal or specific in different cancer types. To address the problem, we introduce a transfer learning framework to discover common CNVs shared across different tumor types as ...
Huanan Zhang, Ze Tian, Rui Kuang
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Distribution and functional impact of DNA copy number variation in the rat
Nature Genetics, 2008The abundance and dynamics of copy number variants (CNVs) in mammalian genomes poses new challenges in the identification of their impact on natural and disease phenotypes. We used computational and experimental methods to catalog CNVs in rat and found that they share important functional characteristics with those in human. In addition, 113 one-to-one
Guryev V. +11 more
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Interest Rises in DNA Copy Number Variations--Along With Questions
Science, 2008At the annual meeting of the American Society of Human Genetics last week, the hot topic was duplicated or missing blocks of DNA, known as copy number variations--the study of which, like any emerging field, is plagued by uncertainty.
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Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
Nature Reviews Molecular Cell Biology, 2023Yutaro Hori, Christoph Engel
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes
Nature Biotechnology, 2022Teng Gao, Hirak Sarkar, Adam Kurkiewicz
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Mitochondrial DNA Copy Number and Incident Heart Failure
Circulation, 2020Yun Soo Hong +2 more
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