Results 301 to 310 of about 108,714 (328)

Isolation and characterisation of DNA cytosine 5-methyltransferase from human placenta

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1983
DNA cytosine 5-methyltransferase has been extensively purified (about 2600-fold) from the soft tissue of human placenta by chromatography on DEAE-cellulose and hydroxyapatite, and by an affinity step on agarose-immobilized S-adenosylhomocysteine. The isolated enzyme has a molecular weight of 135,000 and methylates DNA from various sources in native and
G P, Pfeifer, S, Grünwald, T L, Boehm, D, Drahovsky   +3 more
openaire   +2 more sources

DNA (cytosine-5)-methyltransferase 3B - [Isoform 1]

Targeted Protein Database, 2008
A DNMT3B (DNMT3B , DNA (cytos ine-5)methyltransferase 3B; Swiss-Prot accession number: Q9UBC3) gene deletion construct in which exons 16–19 were deleted was used to generate Dnmt3b-null ES cells and animals. The deleted region encodes the highly conserved PC (proline cysteine) and ENV (glutamic acid, asparagine, valine) motifs that are crucial for ...
openaire   +1 more source

Role of Conformational Fluctuations of Protein toward Methylation in DNA by Cytosine-5-methyltransferase.

Journal of Chemical Theory and Computation, 2018
Methylation of cytosine is the common epigenetic modification in genomes ranging from bacteria to mammals, and aberrant methylation leads to human diseases including cancer.
M. Mondal, Ying Yang, Lijiang Yang, Weitao Yang, Y. Gao   +4 more
semanticscholar   +1 more source

DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia

Molecular Pharmacology, 2007
In this issue of Molecular Pharmacology, Kundakovic et al. (p. 644) present compelling evidence suggesting that the promoters for reelin and GAD67 are coordinately regulated. The regulation occurs at the level of DNA (cytosine-5) methylation. Moreover, the authors present evidence suggesting that pharmacologic inhibition of DNA methyltransferase ...
openaire   +2 more sources

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

Nature Genetics, 1998
M. Okano, Shaoping Xie, E. Li
semanticscholar   +1 more source

[Properties of DNA-(cytosine-5-)-methyltransferase in the brain].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1986
Beef brain DNA-(cytosine-5-)-methyltransferase was partially purified by chromatography on Ultrogel AcA34 and Dyematrex Blue A. The purification was of 360 times and the recovery of 75%. The pH optimum of the reaction is 7.6 NaCl inhibits double stranded DNA methylation, but stimulates single stranded DNA methylation up to 50 mM, before inhibiting ...
A, Pfohl-Leszkowicz, G, Keith, G, Dirheimer   +2 more
openaire   +1 more source

Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells.

Progress in Molecular Biology and Translational Science, 2011
S. Kinney, S. Pradhan
semanticscholar   +1 more source

Gilbert's conjecture: the search for DNA (cytosine-5) demethylases and the emergence of new functions for eukaryotic DNA (cytosine-5) methyltransferases.

Journal of Molecular Biology, 2000
S. S. Smith
semanticscholar   +1 more source

Influence of photoperiod on expression of DNA (cytosine-5) methyltransferases in Atlantic cod.

Gene, 2013
A. Giannetto, K. Nagasawa, S. Fasulo, J. Fernandes   +3 more
semanticscholar   +1 more source

DNA (cytosine-5-)-methyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source