Results 251 to 260 of about 1,557,993 (359)
DNA damage response pathway regulates Nrf2 in response to oxidative stress. [PDF]
Jiang XY+20 more
europepmc +1 more source
Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan+12 more
wiley +1 more source
Consistent asymmetry in DNA damage artefacts across target regions in exome sequencing data. [PDF]
Medina TD, Bennett D, Seoighe C.
europepmc +1 more source
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han+9 more
wiley +1 more source
WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer. [PDF]
Sobajima T+5 more
europepmc +1 more source
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague+8 more
wiley +1 more source
Investigation of DNA Damage and Apoptosis in Bovine Ocular Squamous Cell Carcinoma. [PDF]
Dörtbudak MB, Yener K.
europepmc +1 more source