Results 291 to 300 of about 1,610,430 (355)

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Ambient ultraviolet radiation induces DNA damage in amphibian larvae under semi-natural conditions. [PDF]

J Exp Biol
Hird C, Cramp RL, Franklin CE.
europepmc   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

IFI16 Enhances Chemosensitivity of Breast Cancer Cells by Inhibiting DNA Damage Response. [PDF]

Biomol Ther (Seoul)
Ka NL, Lim GY, Kim SS, Lee MO.
europepmc   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Investigation of radiation-induced DNA damage repair-related genes as diagnostic biomarkers for radiation. [PDF]

J Radiat Res
Zhang Q, Yu Y.
europepmc   +1 more source

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

Advanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong, Hyuna Kwak, Woojin Jeong, Hongwoo Lee, Su‐Ji Jeon, Hyo‐Jun Lee, Pil Joon Seo, Seon‐Yeong Kwak   +7 more
wiley   +1 more source

A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression. [PDF]

Nat Aging
Sproviero D, Payán-Gómez C, Milanese C, Barnhoorn S, Sun S, Gyenis A, Delia D, Lashley T, Hoeijmakers JHJ, Vijg J, Mastroberardino PG.   +10 more
europepmc   +1 more source

High‐Density Boron Nitride Nanotube Composites via Surfactant‐Stabilized Lyotropic Liquid Crystals for Enhanced Space Radiation Shielding

Advanced Functional Materials, EarlyView.
High‐density BNNT films, enabling mechanical robustness and high space radiation shielding effectiveness, are fabricated using surfactant‐stabilized BNNT liquid crystal. Simulations indicate that a 50 g cm−2 BNNT film can reduce radiation exposure by 56% compared to zero shielding, potentially doubling the duration of astronaut missions on the lunar ...
Young‐Kyeong Kim, Ik Jae Lim, Hongjin Lim, Yongbi Joo, Jueun Park, Md Monir Hossain, Hyunjin Cho, Nam‐Ho You, Seokhoon Ahn, Hunsu Lee, Sang Seok Lee, Yongho Joo, Se Youn Moon, Hee Il Yoo, Calista Lum, Cheol Park, Siyoung Q. Choi, Se Gyu Jang   +17 more
wiley   +1 more source

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

Advanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti, Petr Michálek, Zbyněk Heger, Martin Pumera   +3 more
wiley   +1 more source