Results 291 to 300 of about 5,698,803 (355)

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA-positive tumours. [PDF]

Clin Transl Med
Tian C, Gan H.
europepmc   +1 more source

PFOA exposure decreases acrosome reaction and increases DNA oxidative damage by impairing the sperm head shaping in mice

Chuan Wang, Rui Yang, Wei Hu, S. M. Zhang, Feng-Wen Niu, Xiaoyi Zhang, Qinglin Ye, De‐Xiang Xu, Zhihui Zhang, Dongdong Xie   +9 more
openalex   +1 more source

Direct C-Amination of Guanosine with Hydroxylamine-O-Sulfonic Acid. Simplest Model Reaction possibly involved in DNA Damage leading to Carcinogenesis by N-Arylhydroxylamines

, 1972
Yutaka Kawazoe, Guang-Fu Huang
openalex   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response. [PDF]

Invest Ophthalmol Vis Sci
Wang M, Tang J, Li J, Lv J, Zhang Z, Liu Y, Sun H, Gao Y, Chen S, Tang L, Zhang P, Su S, Lu R.   +12 more
europepmc   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Imaging the time course of DNA damage response at a nonrepetitive endogenous locus. [PDF]

Cell Rep Methods
Rybczynski AT, Cottle WT, Chen PT, Kwon J, Shang T, Wang Y, Meneses P, Pangeni S, Park Y, Gavrilov M, Ha T.   +10 more
europepmc   +1 more source

Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond Y. H. Yap, Ka Lai Lee, Philip H. Li, Iris Y. K. Tang, Chak Sing Lau, Shirley C. W. Chan   +6 more
wiley   +1 more source

The role of lncRNA SNHG15 in UV-induced DNA damage repair. [PDF]

PLoS One
Zhang X, Lin J, Fan Z, Zhang S, Yang M, Zhu T, Lu Q, Wang Y.   +7 more
europepmc   +1 more source