Results 31 to 40 of about 36,995 (224)
Track structure simulation of low energy electron damage to DNA using Geant4-DNA [PDF]
Biomedical Physics & Engineering Express 4 (2018) 065009, 2018 Due to the physical and chemical processes that are involved, interactions of ionizing radiations with cells lead to single- and double-strand breaks (SSB and DSB) and base damage to DNA cells. The damage may kill the cells or may be mis-repaired and lead to genetic diseases and cancers. Track structure Monte Carlo simulation of the DNA damage provides
arxiv +1 more source
Tau affects P53 function and cell fate during the DNA damage response [PDF]
Communications Biology 3, 245 (2020), 2020 Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and ...
arxiv +1 more source
Simulation of DNA damage using Geant4-DNA: an overview of the "molecularDNA" example application [PDF]
Prec.Radiat.Oncol. (2023) 1- 11, 2022 The scientific community shows a great interest in the study of DNA damage induction, DNA damage repair and the biological effects on cells and cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far to study these mechanisms using Monte Carlo simulations.
arxiv +1 more source
FEBS Open Bio, 2019 Receptor‐type protein tyrosine phosphatase κ (PTPRK) is considered to be a candidate tumor suppressor. PTPRK dephosphorylates CD133, which is a stem cell marker; phosphorylated CD133 accelerates xenograft tumor growth of colon cancer cells through the ...
Masashi Matsushita +10 more
doaj +1 more source
Molecules, 2020 Mitochondria emerged from bacterial ancestors during endosymbiosis and are crucial for cellular processes such as energy production and homeostasis, stress responses, cell survival, and more.
Karolina Boguszewska +3 more
doaj +1 more source
Calculation of complex DNA damage induced by ions [PDF]
Physical Review E 84, 051918 (2011), 2011 This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be sufficiently effective.
arxiv +1 more source
A mini-review of the diffusion dynamics of DNA-binding proteins: Experiments and models [PDF]
, 2020 In the course of various biological processes, specific DNA-binding proteins must find a particular target sequence/protein or a damaged site on the DNA efficiently. DNA-binding proteins perform this task based on diffusion. Yet, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated ...
arxiv +1 more source
Cold Spring Harbor Perspectives in Biology, 2013 Under favorable conditions DNA can survive for thousands of years in the remains of dead organisms. The DNA extracted from such remains is invariably degraded to a small average size by processes that at least partly involve depurination. It also contains large amounts of deaminated cytosine residues that are accumulated toward the ends of the ...
Matthias Meyer +2 more
openaire +3 more sources
BioTechniques, 2011 Telomere shortening is an important risk factor for cancer and accelerated aging. However, it is becoming evident that oxidatively damaged DNA within the telomere sequence may also cause telomere dysfunction.
Nathan O'Callaghan +3 more
doaj +1 more source
Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations [PDF]
, 2022 The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a vital role in the epigenetic control of gene expression and is believed to be associated with mutagenesis, carcinogenesis, and ageing. To understand the microscopic structural changes in physical properties of DNA and the resulting influence on its function due to ...
arxiv +1 more source