Results 231 to 240 of about 1,030,824 (346)

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair

Oncogene, 2016
Lin-Lin Cao, F. Wei, Y. Du, B. Song, D. Wang, C. Shen, X. Lu, Z. Cao, Q. Yang, Y. Gao, L. Wang, Y. Zhao, H. Wang, Y. Yang, W. Zhu   +14 more
semanticscholar   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Investigation of radiation-induced DNA damage repair-related genes as diagnostic biomarkers for radiation. [PDF]

J Radiat Res
Zhang Q, Yu Y.
europepmc   +1 more source

SUMO-mediated regulation of DNA damage repair and responses.

TIBS -Trends in Biochemical Sciences. Regular ed, 2015
P. Sarangi, Xiaolan Zhao
semanticscholar   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

UCHL3: a crucial deubiquitinase in DNA damage repair and tumor progression. [PDF]

Cancer Cell Int
Liu J, Hu S, Xiao J, Zhou J.
europepmc   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair. [PDF]

Front Cell Dev Biol
Lin J, Zhao G, Feng J, Sun C, Liu C, Li J, Shen Y, Cheng Y.   +7 more
europepmc   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair. [PDF]

Cell Biosci
Wang N, Yang L, Huang Y, Wang Y, Liu M, Yang J, Zeng Z, Xie G, Sun L, Han T, Yu B, Jin J.   +11 more
europepmc   +1 more source