Results 211 to 220 of about 362,053 (261)

Blockade of the KRAS-FOSL1 axis elicits DNA damage repair deficiency exploitable with local and systemic genotoxic therapies

open access: yes
Vicent S   +30 more
europepmc   +1 more source
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Cohesin and DNA damage repair

Experimental Cell Research, 2006
Replicated DNA molecules are physically connected by cohesin complexes from the time of their synthesis in S-phase until they are segregated during anaphase of the subsequent mitosis or meiosis. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle.
Erwan, Watrin, Jan-Michael, Peters
openaire   +2 more sources

Damage and repair of ancient DNA

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Under certain conditions small amounts of DNA can survive for long periods of time and can be used as polymerase chain reaction (PCR) substrates for the study of phylogenetic relationships and population genetics of extinct plants and animals, including hominids.
Mitchell, David   +2 more
openaire   +3 more sources

DNA damage, repair and chromosomal damage

International Journal of Radiation Biology, 1997
An important question in radiobiology is the relationship between primary DNA damage and chromosomal aberrations. What determines the chromosomal aberration frequency, especially in radiosensitive cells? Much evidence points to the double-strand break (dsb) as the critical lesion, however there is controversy over whether it is the initial induction ...
openaire   +2 more sources

DNA Damage and Repair

1991
Some of the background to radiation chemical studies of DNA damage is presented, followed by a review of measurements of such damage and its repair in mammalian cells. While most effort has been placed on the measurement of radiation-induced strand breaks (because assays can be used in the biologically relevant dose range), the radiation-altered bases ...
openaire   +3 more sources

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