Results 201 to 210 of about 362,053 (261)

DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study. [PDF]

Front Genet
Qin K, Hu G, Song E.
europepmc   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer. [PDF]

Cell Death Dis
Yu Y, Wu H, Xiao Y, Qiu J, Hong L, Yang B, Wang J, Wang Z, Shao L, Xu B, Wu J.   +10 more
europepmc   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

PHF20 stabilizes the GAS7-F-actin axis to drive DNA damage repair and chemoresistance in cutaneous squamous cell carcinoma. [PDF]

Cell Death Dis
Li Y, Wen H, Zheng H, Zhen Y, Jia J, Li Z.   +5 more
europepmc   +1 more source

Advances in DNA damage repair mechanisms in stem cells and their applications. [PDF]

Cell Cycle
Wei D, Chang Y, Yang Y, Chen X, Jin S, Huang K, Jiapaer Z, Wang X.   +7 more
europepmc   +1 more source

NOP58 modulates radiosensitivity in non-small cell lung cancer via DDX18-mediated DNA damage repair. [PDF]

J Radiat Res
Jiang Y, Zhang W, Bao Y, Su F, Wang B.
europepmc   +1 more source