Results 221 to 230 of about 362,053 (261)

Repairing DNA-methylation damage

Nature Reviews Molecular Cell Biology, 2004
Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism.
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DNA DAMAGE AND REPAIR IN PLANTS

Annual Review of Plant Physiology and Plant Molecular Biology, 1996
▪ Abstract  The biological impact of any DNA damaging agent is a combined function of the chemical nature of the induced lesions and the efficiency and accuracy of their repair. Although much has been learned from microbes and mammals about both the repair of DNA damage and the biological effects of the persistence of these lesions, much remains to be ...
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Repair of Damaged DNA in Bacteria

1977
Publisher Summary The chapter describes the methods of DNA repair mechanisms—genetically and biochemically—the nature of the repair modes and their effect on survival and mutation. The structure of DNA is basically open to three kinds of damage, all of which may lead to lethal or mutational events.
B E, Moseley, E, Williams
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DNA Damage and Repair in Alzheimers Disease

Current Alzheimer Research, 2009
The vast majority of the studies performed so far and aimed at elucidating DNA repair mechanisms has been performed in mitotic cells, such as transformed or cancer cell lines. Therefore, our understanding of DNA repair mechanisms in post-mitotic cells, such as neurons, remains one of the most exciting areas for future investigations.
COPPEDE', FABIO, MIGLIORE, LUCIA
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Chromatin and DNA damage repair

Russian Journal of Genetics, 2011
In eukaryotic cells, inheritance of both exact DNA sequence and its arrangement into the chromatin is critical for maintaining stability of the genome. Various DNA lesions induced by endogenous and exogenous factors make this maintenance problematic. To understand completely how cells resolve this problem the knowledge on the nature of these lesions ...
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Repairable Damage in DNA: Overview

1975
Due to the central functional role of DNA and the fact that each cell contains only one or at the most a few copies of each chromosome, damage to DNA has more severe implications for the functional integrity of the cell than does damage to most other cellular components.
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Introduction: DNA Damage and Repair

1983
The concept that cancer may be induced by the interaction of a carcinogen with DNA is widely accepted, although it is becoming increasingly clear that some carcinogens do not interact with DNA to a detectable extent. The carcinogens have been classified into two broad categories, genotoxic and non-genotoxic or epigenetic.
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Dna Damage and Repair

2010
Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity.
Hammond, E.M., Pires, I.M.; id_orcid 0000-0002-0417-2710, Giaccia, A.J.   +2 more
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DNA Damage Repair

2017
DNA damage, when occurring in cancer-related genes, may lead to tumorigenesis. In normal cells, such DNA alterations activate a complex machinery of DNA damage repair. Genomic defects in DNA damage repair genes are known to be major drivers of cancer development and progression, in particular in breast and colon cancer.
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Revolutionizing DNA Repair Research and Cancer Therapy With CRISPR–Cas Screens

Nature Reviews Molecular Cell Biology, 2023
Stephen P Jackson, Almudena Serrano-Benítez   +1 more
exaly