Results 271 to 280 of about 377,653 (310)

DNA Damage and Repair

1991
Some of the background to radiation chemical studies of DNA damage is presented, followed by a review of measurements of such damage and its repair in mammalian cells. While most effort has been placed on the measurement of radiation-induced strand breaks (because assays can be used in the biologically relevant dose range), the radiation-altered bases ...
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Damage and repair of ancient DNA

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Under certain conditions small amounts of DNA can survive for long periods of time and can be used as polymerase chain reaction (PCR) substrates for the study of phylogenetic relationships and population genetics of extinct plants and animals, including hominids.
Mitchell, David, Willerslev, Eske, Hansen, Anders   +2 more
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Repairing DNA-methylation damage

Nature Reviews Molecular Cell Biology, 2004
Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism.
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Repair of Damaged DNA in Bacteria

1977
Publisher Summary The chapter describes the methods of DNA repair mechanisms—genetically and biochemically—the nature of the repair modes and their effect on survival and mutation. The structure of DNA is basically open to three kinds of damage, all of which may lead to lethal or mutational events.
B E, Moseley, E, Williams
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DNA Damage and Repair in Alzheimers Disease

Current Alzheimer Research, 2009
The vast majority of the studies performed so far and aimed at elucidating DNA repair mechanisms has been performed in mitotic cells, such as transformed or cancer cell lines. Therefore, our understanding of DNA repair mechanisms in post-mitotic cells, such as neurons, remains one of the most exciting areas for future investigations.
COPPEDE', FABIO, MIGLIORE, LUCIA
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Chromatin and DNA damage repair

Russian Journal of Genetics, 2011
In eukaryotic cells, inheritance of both exact DNA sequence and its arrangement into the chromatin is critical for maintaining stability of the genome. Various DNA lesions induced by endogenous and exogenous factors make this maintenance problematic. To understand completely how cells resolve this problem the knowledge on the nature of these lesions ...
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Repairable Damage in DNA: Overview

1975
Due to the central functional role of DNA and the fact that each cell contains only one or at the most a few copies of each chromosome, damage to DNA has more severe implications for the functional integrity of the cell than does damage to most other cellular components.
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Introduction: DNA Damage and Repair

1983
The concept that cancer may be induced by the interaction of a carcinogen with DNA is widely accepted, although it is becoming increasingly clear that some carcinogens do not interact with DNA to a detectable extent. The carcinogens have been classified into two broad categories, genotoxic and non-genotoxic or epigenetic.
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Dna Damage and Repair

2010
Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity.
Hammond, E.M., Pires, I.M.; id_orcid 0000-0002-0417-2710, Giaccia, A.J.   +2 more
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Loop extrusion as a mechanism for formation of DNA damage repair foci

Nature, 2021
Coline Arnould, Vincent Rocher, Thomas Clouaire   +2 more
exaly