Results 301 to 310 of about 1,030,824 (346)

Chromatin and DNA damage repair

Russian Journal of Genetics, 2011
In eukaryotic cells, inheritance of both exact DNA sequence and its arrangement into the chromatin is critical for maintaining stability of the genome. Various DNA lesions induced by endogenous and exogenous factors make this maintenance problematic. To understand completely how cells resolve this problem the knowledge on the nature of these lesions ...
openaire   +2 more sources

Plant DNA-damage repair/toleration 100 protein repairs UV-B-induced DNA damage

DNA Repair, 2014
We report the characterization of VvDRT100-L, a grape DNA-damage repair/toleration 100 protein. VvDRT100-L has nine leucine-rich repeats and belongs to the plant DRT100 protein family. VvDRT100-L is expressed abundantly in green organs of grapevines, including tendrils, leaves, and green berry skins.
Nozomi Fujimori, Nana Suzuki, Yuko Nakajima, Shunji Suzuki   +3 more
openaire   +2 more sources

Repairable Damage in DNA: Overview

1975
Due to the central functional role of DNA and the fact that each cell contains only one or at the most a few copies of each chromosome, damage to DNA has more severe implications for the functional integrity of the cell than does damage to most other cellular components.
openaire   +2 more sources

DNA Damage Repair

2017
DNA damage, when occurring in cancer-related genes, may lead to tumorigenesis. In normal cells, such DNA alterations activate a complex machinery of DNA damage repair. Genomic defects in DNA damage repair genes are known to be major drivers of cancer development and progression, in particular in breast and colon cancer.
openaire   +1 more source

Introduction: DNA Damage and Repair

1983
The concept that cancer may be induced by the interaction of a carcinogen with DNA is widely accepted, although it is becoming increasingly clear that some carcinogens do not interact with DNA to a detectable extent. The carcinogens have been classified into two broad categories, genotoxic and non-genotoxic or epigenetic.
openaire   +2 more sources

Dna Damage and Repair

2010
Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity.
Hammond, E.M., Pires, I.M., Giaccia, A.J.   +2 more
openaire   +2 more sources

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Nature, 2007
Derrick J. Rossi, D. Bryder, J. Seita, A. Nussenzweig, J. Hoeijmakers, I. Weissman   +5 more
semanticscholar   +1 more source

Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Michael L Cheng, Glenn J Hanna, Heather A Parsons   +2 more
exaly  

REPAIRABLE DAMAGE IN DNA

1978
ABSTRACT Important contributions to the elucidation of the role of DNA repair for cell viability, mutagenesis, malignant transformation and cell degeneration are expected from experiments in which individual DNA lesions of known chemical structure are investigated.
openaire   +1 more source

DNA damage and repair in age-related inflammation

Nature Reviews Immunology, 2022
Yang Zhao, Andrei Seluanov, Vera Gorbunova   +2 more
exaly