Results 111 to 120 of about 1,846,477 (392)

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1 [PDF]

, 2001
In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor.
Carpenter, Phillip B., Dunphy, William G., Morales, Julio C., Xia, Zhenfang   +3 more
core  

DNA Damage and Its Links to Neurodegeneration [PDF]

, 2017
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of ...
Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei   +2 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Nature Communications, 2018
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing.
M. Krajewska, Ruben Dries, A. Grassetti, S. Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, E. Chipumuro, Tinghu Zhang, A. Greenleaf, Guocheng Yuan, N. Gray, R. Young, M. Geyer, S. Gerber, R. George   +19 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE

Паёми Сино, 2017
Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage ...
M.A. NORMATOVA
doaj   +1 more source

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

Frontiers in Oncology, 2020
RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng, Xiangbing Meng, Shujie Yang, Shujie Yang, Vanessa J. A. Camp   +4 more
doaj   +1 more source

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. [PDF]

, 2016
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer.
Bocek, Michael, Chédin, Frédéric, Cimprich, Karlene A, Crossley, Madzia P, Sanz, Lionel A, Sollier, Julie, Stork, Caroline Townsend, Swigut, Tomek   +7 more
core   +3 more sources

mTORC1 pathway in DNA damage response

Biopolymers and Cell, 2019
Living organisms have evolved various mechanisms to control their metabolism and response to various stresses, allowing them to survive and grow in different environments In eukaryotes, the highly conserved mechanistic target of rapamycin (mTOR ...
Yinxing Ma, L. Silveri, J. LaCava, Y. Vassetzky, S. Dokudovskaya, A. Mouche, Jérôme Archambeau, C. Ricordel, L. Chaillot, -. Nico, las Bigot, T. Guillaudeux, Muriel, Grenon, R. Pedeux   +14 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source