Results 211 to 220 of about 7,503,880 (242)
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Transcriptional responses to DNA damage
Current Opinion in Microbiology, 2001In Escherichia coli, DNA repair and protective responses are regulated at the transcriptional level. Regulatory mechanisms have evolved that allow cells to respond to DNA damage by mounting the appropriate responses. The regulatory proteins controlling these responses are activated when they recognize the presence of a specific DNA damaging agent, the ...
Volkert, Michael R., Landini, Paolo
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Accolades for the DNA Damage Response
New England Journal of Medicine, 2015Given the importance to human health of the DNA damage response, it's not surprising that the Lasker Award for Basic Medical Research is being given to two scientists who have elucidated this response: Evelyn Witkin for work in bacteria and Stephen Elledge for work in eukaryotes.
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Cellular responses to DNA damage
Current Opinion in Cell Biology, 1998The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death.
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ATM and Cellular Response to DNA Damage
2006Most human cancers display a myriad of genetic changes, a characteristic often attributed to genome instability. Cytogenetic studies have long identified chromosomal aberrations as a hallmark of human tumours, but the causes and consequences of genomic defects in tumours still remain to be fully understood. In particular, the role of genome instability
Lavin, Martin F. +6 more
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The DNA damage response during DNA replication
Current Opinion in Cell Biology, 2005Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid cohesion, DNA recombination, transcription and cell cycle progression. Replication forks stall or collapse at DNA lesions or problematic genomic regions, and these events have often been associated with recombination and chromosomal ...
M. Foiani, D. Branzei
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Checkpoint response to DNA damage
DNA Repair, 2009M. Muzi-Falconi, J. Petrini
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2014
This chapter reviews the current knowledge about the mechanism of the LexA/RecA regulated response and its output in Escherichia coli, stressing newly emerging areas such as regulation of RecA filament formation and management of specialized DNA repair polymerases. It also talks about the SOS response in other bacterial species and its implications for
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This chapter reviews the current knowledge about the mechanism of the LexA/RecA regulated response and its output in Escherichia coli, stressing newly emerging areas such as regulation of RecA filament formation and management of specialized DNA repair polymerases. It also talks about the SOS response in other bacterial species and its implications for
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Nature, 2021Juan Garaycoechea +2 more
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Functional interrogation of DNA damage response variants with base editing screens
Cell, 2021Raquel Cuella Martin, Raúl Rabadan
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The DNA damage response to transcription stress
Nature Reviews Molecular Cell Biology, 2019Jürgen Marteijn +2 more
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