Results 211 to 220 of about 716,098 (263)

Predicting DNA damage response using synthetic cell painting profiles and experimental analysis. [PDF]

iScience
Seo C, Lim H, Piao Z, Koh YJ, Lee SJ.
europepmc   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Cholangiocytes' primary cilia regulate DNA damage response and repair. [PDF]

Am J Physiol Gastrointest Liver Physiol
Peixoto E, Pant K, Richard S, Popoca JP, Abrahante JE, Czaja W, Gradilone SA.   +6 more
europepmc   +1 more source

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition. [PDF]

Front Cell Dev Biol
Giuntini F, Whitfield JR, Massó-Vallés D, Soucek L.   +3 more
europepmc   +1 more source

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

Advanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande, Ainhoa Urbiola, Cristina Ederra, Tomas Muñoz Santoro, Beatrice Pinci, Alvaro Teijeira, Carlos Ortiz de Solórzano   +9 more
wiley   +1 more source

Merkel Cell Polyomavirus and DNA Damage Response (DDR): Transcriptional Analysis of DDR Pathways in the Context of Merkel Cell Carcinoma. [PDF]

Cancers (Basel)
Messina S, Mallardo D, Ferlosio A, Festino L, Trojaniello C, Di Trolio R, Ciotti M, Ascierto PA, Pietropaolo V, Passerini S.   +9 more
europepmc   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

The multifaceted role of ATM protein in neural stem/progenitor cell biology and neurogenesis: beyond DNA damage response. [PDF]

Front Pharmacol
Boni G, Grilli M.
europepmc   +1 more source

Activation of the ATM-Chk2 DNA damage response pathway by Newcastle disease virus enhances viral replication. [PDF]

Vet Res
Yan W, Dong C, Liu X, Li H, Peng J, Jiang F, Li H, Stoeger T, Wajid A, Dodovski A, Mingala CN, Andreychuk DB, Yin R.   +12 more
europepmc   +1 more source